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ChemicalBook >> CAS DataBase List >> HLM006474

HLM006474

HLM006474 price.
  • $68 - $1470
  • Product name: HLM006474
  • CAS: 353519-63-8
  • MF: C25H25N3O2
  • MW: 399.48
  • EINECS:
  • MDL Number:MFCD02168344
  • Synonyms:HLM006474;E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem;CS-1224;8-Quinolinol, 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-;7-((4-Ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl)-2-methylquinolin-8-ol;HLM006474,inhibit,HLM 006474,Early 2 Factor (E2F),Inhibitor,HLM-006474
18 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 5mg
  • 10
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3384AH
  • Product description7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
  • Packaging5mg
  • Price$174
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number28276
  • Product descriptionHLM006474
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28276
  • Product descriptionHLM006474
  • Packaging10mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28276
  • Product descriptionHLM006474
  • Packaging25mg
  • Price$268
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002142
  • Product descriptionHLM006474 98+%
  • Packaging5mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002142
  • Product descriptionHLM006474 98+%
  • Packaging10mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002142
  • Product descriptionHLM006474 98+%
  • Packaging50mg
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002142
  • Product descriptionHLM006474 98+%
  • Packaging100mg
  • Price$1470
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC34342
  • Product descriptionHLM006474
  • Packaging250mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC34342
  • Product descriptionHLM006474
  • Packaging1g
  • Price$1400
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1260
  • Product descriptionHLM006474 ≥98% (HPLC)
  • Packaging5MG
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number324461
  • Product descriptionE2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem
    The E2F Inhibitor, HLM006474, also referenced under CAS 353519-63-8, controls the biological activity of E2F. This small molecule/inhibitor is primarily used for Cancer applications.
  • Packaging10mg
  • Price$182
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1260
  • Product descriptionHLM006474 ≥98% (HPLC)
  • Packaging25MG
  • Price$462
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number5283
  • Product descriptionHLM006474 ≥98%(HPLC)
  • Packaging10
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number5283
  • Product descriptionHLM006474 ≥98%(HPLC)
  • Packaging50
  • Price$597
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberH456335
  • Product descriptionHLM006474
  • Packaging50mg
  • Price$340
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3384AH 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol 5mg $174 2021-12-16 Buy
Cayman Chemical 28276 HLM006474 5mg $68 2024-03-01 Buy
Cayman Chemical 28276 HLM006474 10mg $121 2024-03-01 Buy
Cayman Chemical 28276 HLM006474 25mg $268 2024-03-01 Buy
Crysdot CD31002142 HLM006474 98+% 5mg $245 2021-12-16 Buy
Crysdot CD31002142 HLM006474 98+% 10mg $350 2021-12-16 Buy
Crysdot CD31002142 HLM006474 98+% 50mg $1050 2021-12-16 Buy
Crysdot CD31002142 HLM006474 98+% 100mg $1470 2021-12-16 Buy
DC Chemicals DC34342 HLM006474 250mg $750 2021-12-16 Buy
DC Chemicals DC34342 HLM006474 1g $1400 2021-12-16 Buy
Sigma-Aldrich SML1260 HLM006474 ≥98% (HPLC) 5MG $118 2024-03-01 Buy
Sigma-Aldrich 324461 E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem
The E2F Inhibitor, HLM006474, also referenced under CAS 353519-63-8, controls the biological activity of E2F. This small molecule/inhibitor is primarily used for Cancer applications.
10mg $182 2024-03-01 Buy
Sigma-Aldrich SML1260 HLM006474 ≥98% (HPLC) 25MG $462 2024-03-01 Buy
Tocris 5283 HLM006474 ≥98%(HPLC) 10 $144 2021-12-16 Buy
Tocris 5283 HLM006474 ≥98%(HPLC) 50 $597 2021-12-16 Buy
TRC H456335 HLM006474 50mg $340 2021-12-16 Buy

Properties

Boiling point :588.7±50.0 °C(Predicted)
Density :1.227±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:25.0(Max Conc. mg/mL);62.58(Max Conc. mM)
pka :4.36±0.50(Predicted)
form :Off-white solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:

Description

HLM006474 is a non-selective inhibitor of the transcription factor E2F (IC50 = 29.8 μM for E2F4). It inhibits DNA binding to E2F1, E2F2, and E2F4 in A375 melanoma cells when used at a concentration of 40 μM. HLM006474 (40 μM) decreases protein levels of E2F4 and cyclin D3 and induces apoptosis in A375 cells. It also induces apoptosis in MDA-MB-231, but not MCF-7, cells and inhibits the growth of cancer cells in a panel of 17 lung cancer cell lines (IC50s = 15.5-75.1 μM). HLM006474 reduces tumor growth in retinoblastoma-prone Chx10Cre;Rbfl/fl;p107-/- mice and in an A375 mouse xenograft model when administered at a dose of 100 mg/kg and 2 mg per mouse, respectively.