K-Ras inhibitor
- CAS No.
- 1469338-01-9
- Chemical Name:
- K-Ras inhibitor
- Synonyms
- 6H05;CS-1817;K-Ras inhibitor;6H05/K-Ras inhibitor;6H05 trifluoroacetate;K-Ras inhibitor USP/EP/BP;6H05 trifluoroacetate 1469338-01-9(free base);1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide;4-Piperidinecarboxamide, 1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-;1-{2-[(4-chlorophenyl)sulfanyl]acetyl}-N-(2-{[2-(dimethylamino)ethyl]disulfanyl}ethyl)piperidine-4-carboxamide
- CBNumber:
- CB92729348
- Molecular Formula:
- C20H30ClN3O2S3
- Molecular Weight:
- 476.12
- MDL Number:
- MFCD28167831
- MOL File:
- 1469338-01-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
K-Ras inhibitor price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A8902 | 6H05 | 1469338-01-9 | 5mg | $140 | 2021-12-16 | Buy |
| Crysdot | CD31003405 | 6H05 98+% | 1469338-01-9 | 5mg | $360 | 2021-12-16 | Buy |
| DC Chemicals | DC7736 | 6H05 >98% | 1469338-01-9 | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC7736 | 6H05 >98% | 1469338-01-9 | 250mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC7736 | 6H05 >98% | 1469338-01-9 | 1g | $1800 | 2021-12-16 | Buy |
K-Ras inhibitor Chemical Properties,Uses,Production
Biological Activity
6h05 is a selective inhibitorof the common oncogenic mutant k-ras (g12c). 6h05 allosterically modifies and inhibits the oncogenic g12c mutant of highly homologous protein h-ras, not affecting the wild-type k-ras [1].k-ras plays an important role in human cancer, cause mutations in k-ras are the most common activating lesions in human cancer[2]. 6h05 modifies the gdp-bound k-ras (g12c) the most, which can be and be applied as the starting point for drug-discovery efforts targeting k-ras (g12c) and eventually other alleles of k-ras. 6h05 can be used as an intermediate for the synthesis of oncogenic k-ras (g12c) inhibitors [3, 4].although it’s necessary to perform continued chemical optimization of 6h05 to be assessed in vivo, preliminary evaluation of 6h05 in lung cancer cell lines suggests that 6h05 shows allele-specific impairment of k-ras function[1]. there are questions still need to be illustrated that the selectivity and efficiency of 6h05 in vivo, as well as its effects on the subcellular localization of other farnesylated gtpases should be assessed further[1, 3].questions still need to be answered surrounding the in vivo selectivity and efficacy of 6h05, including its effects on the subcellular localization of other farnesylated gtpases [3].
References
[1] ostrem jm, peters u, sos ml, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions[j]. nature, 2013, 503(7477): 548-551.
[2] mccormick f. kras as a therapeutic target[j]. clinical cancer research, 2015, 21(8): 1797-1801.
[3] milroy l-g,ottmann c. the renaissance of ras[j]. acs chemical biology, 2014, 9(11): 2447-2458.
[4] lu sy, li s,zhang j. harnessing allostery: a novel approach to drug discovery[j]. medicinal research reviews, 2014, 34(6): 1242-1285.
K-Ras inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6005 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
