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PD-321852
- CAS No.
- 622856-21-7
- Chemical Name:
- PD-321852
- Synonyms
- PD-321852;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2,6-dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]-
- CBNumber:
- CB92731118
- Molecular Formula:
- C24H19Cl2N3O3
- Molecular Weight:
- 468.33
- MDL Number:
- MOL File:
- 622856-21-7.mol
Last updated:2023-03-31 09:12:57
PD-321852 Chemical Properties,Uses,Production
Description
PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.
PD-321852 Preparation Products And Raw materials
Raw materials
Preparation Products
PD-321852 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
PD-321852
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2,6-dichlorophenyl)-9-hydroxy-6-[3-(methylamino)propyl]-
622856-21-7