ChemicalBook >> CAS DataBase List >>N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) structure

CAS No.: 164204-38-0

Chemical Name:: N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

Synonyms: Phosphoramidon (Disodium);CRDWMOVRQCMROH-HIKRQZGHSA-N;N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt;N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1);N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

CBNumber:: CB92744622

Molecular Formula:: C23H35N3NaO10P

Molecular Weight:: 567.51

MDL Number:

MOL File:: 164204-38-0.mol

MSDS File:: SDS

Last updated:2024-07-02 08:55:41

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N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Properties

storage temp.	Desiccate at -20°C
solubility	≥58.7 mg/mL in DMSO; insoluble in EtOH; ≥52.5 mg/mL in H2O
form	solid
color	White to off-white
Water Solubility	Soluble to 100 mM in water
FDA UNII	3F7O684NXF

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	15113	Phosphoramidon (sodium salt) ≥98%	164204-38-0	1mg	$86	2024-03-01	Buy
Cayman Chemical	15113	Phosphoramidon (sodium salt) ≥98%	164204-38-0	5mg	$169	2024-03-01	Buy
Cayman Chemical	15113	Phosphoramidon (sodium salt) ≥98%	164204-38-0	10mg	$296	2024-03-01	Buy
Cayman Chemical	15113	Phosphoramidon (sodium salt) ≥98%	164204-38-0	25mg	$629	2024-03-01	Buy
TRC	P359000	Phosphoramidon disodium salt	164204-38-0	25mg	$535	2021-12-16	Buy

Product number	Packaging	Price	Buy
15113	1mg	$86	Buy
15113	5mg	$169	Buy
15113	10mg	$296	Buy
15113	25mg	$629	Buy
P359000	25mg	$535	Buy

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Chemical Properties,Uses,Production

Description

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with K_i values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (K_i = 3.5 μM). Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.

Uses

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

storage

Store at -20°C

References

[1]. ikegawa r, matsumura y, tsukahara y, et al. phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme. biochem biophys res commun, 1990, 171(2): 669-675.
[2]. matsumura y, ikegawa r, hisaki k, et al. conversion of big endothelin-1 to endothelin-1 by phosphoramidon-sensitive metalloproteinase derived from aortic endothelial cells. j cardiovasc pharmacol, 1991, 17 suppl 7: s65-7.
[3]. matsuura a, okumura h, ashizawa n, et al. big endothelin-1-induced sudden death is inhibited by phosphoramidon in mice. life sci, 1992, 50(21): 1631-1638.

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Suppliers

Global( 35)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7854	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Target molecule Corp.	857-239-0968	service1@targetmol.com	United States	2559	60
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58

Supplier	Advantage
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
MedChemexpress LLC	58
TargetMol Chemicals Inc.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Target molecule Corp.	60
Fan De(Beijing) Biotechnology Co., Ltd.	58

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Spectrum

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)(164204-38-0)¹HNMR

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) Phosphoramidon (Disodium) CRDWMOVRQCMROH-HIKRQZGHSA-N N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) 164204-38-0 C23H34N3Na2O10P Inhibitors