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N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)

化学構造式
164204-38-0
CAS番号.
164204-38-0
化学名:
别名:
英語名:
N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
英語别名:
Phosphoramidon (Disodium);CRDWMOVRQCMROH-HIKRQZGHSA-N;N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt;N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1);N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
CBNumber:
CB92744622
化学式:
C23H35N3NaO10P
分子量:
567.51
MOL File:
164204-38-0.mol

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) 物理性質

貯蔵温度 :
Desiccate at -20°C
溶解性:
≥58.7 mg/mL in DMSO; insoluble in EtOH; ≥52.5 mg/mL in H2O
外見 :
solid
色:
White to off-white
水溶解度 :
Soluble to 100 mM in water

安全性情報

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCP359000
Phosphoramidon Disodium Salt 		164204-38-0 2.5mg ￥44300 2023-06-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCP359000
Phosphoramidon Disodium Salt 		164204-38-0 25mg ￥184800 2023-06-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCP359000
Phosphoramidon Disodium Salt 		164204-38-0 100mg ￥530500 2023-06-01 購入

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) 化学特性,用途語,生産方法

説明

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 μM). Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.

使用

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) 上流と下流の製品情報

原材料

準備製品

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1) 生産企業

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  スペクトルデータ(1HNMR)

N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)(164204-38-0)1HNMR
  • 164204-38-0
  • N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
  • Phosphoramidon (Disodium)
  • CRDWMOVRQCMROH-HIKRQZGHSA-N
  • N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
  • N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
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