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2,3-Naphthalenedicarboxylic Anhydride

CAS No.
716-39-2
Chemical Name:
2,3-Naphthalenedicarboxylic Anhydride
Synonyms
EA253;2,3-NAPHTHALI;2,3-NAPHTHALIC ANHYDRIDE;naphtho[2,3-c]furan-1,3-dione;benzo[f][2]benzofuran-1,3-dione;benzo[f]isobenzofuran-1,3-quinone;2,3-Napthalenedicarboxycanhydride;2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE;2,3-NaphthalenedicarboxylicAnhydride>1,3-Dihydronaphtho[2,3-c]furan-1,3-dione
CBNumber:
CB9286597
Molecular Formula:
C12H6O3
Molecular Weight:
198.17
MDL Number:
MFCD00059091
MOL File:
716-39-2.mol
Last updated:2024-12-18 14:15:32

2,3-Naphthalenedicarboxylic Anhydride Properties

Melting point 246 °C
Boiling point 275-280 °C(Press: 100 Torr)
Density 1.449±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color Pale Beige
Stability Moisture Sensitive
InChI InChI=1S/C12H6O3/c13-11-9-5-7-3-1-2-4-8(7)6-10(9)12(14)15-11/h1-6H
InChIKey IZJDCINIYIMFGX-UHFFFAOYSA-N
SMILES O1C(=O)C2=CC3C(C=C2C1=O)=CC=CC=3
EPA Substance Registry System Naphtho[2,3-c]furan-1,3-dione (716-39-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Safety Statements  22-24/25
HS Code  2917.39.7000

2,3-Naphthalenedicarboxylic Anhydride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S876682 2,3-NAPHTHALIC ANHYDRIDE Aldrich 716-39-2 50mg $110 2024-03-01 Buy
TCI Chemical N0530 2,3-Naphthalenedicarboxylic Anhydride >95.0%(GC)(T) 716-39-2 25g $192 2024-03-01 Buy
TCI Chemical N0530 2,3-Naphthalenedicarboxylic Anhydride >95.0%(GC)(T) 716-39-2 250g $772 2024-03-01 Buy
TRC N363000 2,3-NAPHTHALIC ANHYDRIDE 716-39-2 5g $100 2021-12-16 Buy
TRC N363000 2,3-NAPHTHALIC ANHYDRIDE 716-39-2 1g $80 2021-12-16 Buy
Product number Packaging Price Buy
S876682 50mg $110 Buy
N0530 25g $192 Buy
N0530 250g $772 Buy
N363000 5g $100 Buy
N363000 1g $80 Buy

2,3-Naphthalenedicarboxylic Anhydride Chemical Properties,Uses,Production

Appearance

2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE is a pale Beige Solid.

Description

A few years ago, the product was still synthesized from the corresponding diacid, but in recent years, it has been difficult to find the shadow of the diacid in the market, and the sales of this product have been repeatedly restricted, resulting in high prices.

Uses

2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.

Preparation

Add anhydrous tetrahydrofuran (its mass ratio to maleic anhydride is 1.5:1), cat-1 (0.05 mole), maleic anhydride (1 mole), and o-phthalaldehyde (1.5 mole) to the reactor. After adding triethylamine (5 moles), adjust the temperature below -40°C. Silicon tetrachloride (4 moles) was added dropwise to the reaction system and the reaction was placed at -40 °C for 4 h. The mixture was heated to reflux for 20 h. After the end of the reaction, concentrating the solution to a certain concentration with diatomaceous earth filtration. A light yellow solid, namely 2,3-Naphthalenedicarboxylic Anhydride, is obtained by precipitation, filtration, recrystallization and drying. Its yield reaches 88%.
2,3-Naphthalenedicarboxylic Anhydride

36659-22-0
716-39-2
Synthesis of 2,3-Naphthalenedicarboxylic Anhydride from 4,9-Epoxybenz[f]isobenzofuran-1,3-dione, 3a,4,9,9a-tetrahydro-
Global( 157)Suppliers
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Changzhou uniringchem Co., Ltd.
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Alchem Pharmtech,Inc.
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CONIER CHEM AND PHARMA LIMITED
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Richest Group Ltd
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View Lastest Price from 2,3-Naphthalenedicarboxylic Anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE  pictures 2022-06-10 2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE
716-39-2
US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE pictures 2019-07-06 2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE
716-39-2
US $2.00 / kg 1kg 99% ask Career Henan Chemical Co
2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE 1,3-Dihydronaphtho[2,3-c]furan-1,3-dione benzo[f][2]benzofuran-1,3-dione benzo[f]isobenzofuran-1,3-quinone 2,3,NAPHTHALENEDICARBOXYLIC ACIDANHYDRIDE naphtho[2,3-c]furan-1,3-dione 2,3-NAPHTHALIC ANHYDRIDE 2,3-NAPHTHALI 2,3-NaphthalenedicarboxylicAnhydride> 2,3-NAPHTHALENEDICARBOXYLIC ANHYDRIDE ISO 9001:2015 REACH EA253 2,3-Napthalenedicarboxycanhydride 716-39-2 Exciton Chirality CD Method (for Primary Amino Groups) Enantiomer Excess & Absolute Conefiguration Determination Absolute Conefiguration Determination (Exciton Chirality CD Method) Absolute Configuration Determination (Exciton Chirality CD Method) Analytical Chemistry Enantiomer Excess & Absolute Configuration Determination Exciton Chirality CD Method (for Primary Amino Groups)