ChemicalBook >> CAS DataBase List >>4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile structure

CAS No.: 1263373-43-8

Chemical Name:: 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Synonyms: NVP-2;NVP-2, 10 mM in DMSO;inhibit,Apoptosis,Cyclin dependent kinase,CDK,NVP-2,Inhibitor,CRBN,CDK9,Leukemia,NVP 2,NVP2;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylami)cyclohexylami)-2,4'-bipyridin-6-ylami)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile;4-[[[5’-Chloro-2’-[[trans-4-[[(R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-[2,4’-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile;4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile;2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-

CBNumber:: CB92995844

Molecular Formula:: C27H37ClN6O2

Molecular Weight:: 513.07

MDL Number:: MFCD28385769

MOL File:: 1263373-43-8.mol

Last updated:2025-01-27 09:38:02

Request For Quotation

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Properties

Boiling point	704.5±60.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Ethanol: soluble
form	A solid
pka	9.14±0.40(Predicted)
color	White to yellow
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3069	NVP-2 ≥98% (HPLC)	1263373-43-8	5MG	$207	2022-05-15	Buy
Sigma-Aldrich	SML3069	NVP-2 ≥98% (HPLC)	1263373-43-8	25MG	$827	2022-05-15	Buy
Tocris	6535	NVP2 ≥97%(HPLC)	1263373-43-8	5	$238	2021-12-16	Buy
TRC	N925775	NVP-2	1263373-43-8	1mg	$495	2021-12-16	Buy
Usbiological	461045	NVP-2	1263373-43-8	1mg	$885	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML3069	5MG	$207	Buy
SML3069	25MG	$827	Buy
6535	5	$238	Buy
N925775	1mg	$495	Buy
461045	1mg	$885	Buy

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Chemical Properties,Uses,Production

Uses

NVP-2, is a CDK9 inhibitor with an IC50 of 0.5 nM.

Biological Activity

NVP-2 is an ATP-competitive, highly potent and selective cyclin-dependent kinase CDK9 inhibitor (human Cdk9/CycT1 IC50 = 0.3 nM with 6 μM ATP; DYRK1B IC50 = 350 nM; CDK7 IC50 >10 ?M; 0-63% inhibition of 366 other kinases at 1 μM, including CDK2/3/4/5/8). NVP-2 inhibits RNA Pol II-mediated transcription by blocking Cdk9-dependent RNA Pol II CTD phosphorylation (250 nM for 1-24 hrs; MOLT4 cells), displaying higher apoptosis-inducing and antiproliferation efficacy than the CDK2/7/9 inhibitor SNS-032 (BMS-387032) in leukemia cultures (MOLT4 IC50 = 9 nM/NVP-2 vs. 173 nM/SNS-032).

storage

Store at -20°C

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	202	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30233	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	914	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3512	58

Supplier	Advantage
Hubei Chuchang Biotech Co., Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nanjing Doge Biomedical Technology Co., Ltd	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Hebei Miaoyin Technology Co.,Ltd	58

View Lastest Price from 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-02-14	NVP-2 1263373-43-8	US $0.00-0.00 / MG	1MG	98	10G	Hubei Chuchang Biotech Co., Ltd.
	2024-11-18	NVP-2 1263373-43-8	US $50.00-122.00 / mg		99.76%	10g	TargetMol Chemicals Inc.

NVP-2
1263373-43-8
US $0.00-0.00 / MG
98
Hubei Chuchang Biotech Co., Ltd.

NVP-2
1263373-43-8
US $50.00-122.00 / mg
99.76%
TargetMol Chemicals Inc.

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile Spectrum

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile(1263373-43-8)¹HNMR

1263373-43-8(4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile)Related Search:

4'-Benzyloxy-2'-hydroxyacetophenone

4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile NVP-2 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile 2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro- inhibit,Apoptosis,Cyclin dependent kinase,CDK,NVP-2,Inhibitor,CRBN,CDK9,Leukemia,NVP 2,NVP2 4-[[[5’-Chloro-2’-[[trans-4-[[(R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-[2,4’-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylami)cyclohexylami)-2,4'-bipyridin-6-ylami)methyl)tetrahydro-2H-pyran-4-carbonitrile NVP-2, 10 mM in DMSO 1263373-43-8