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RQ-00203078

RQ-00203078 Structure
RQ-00203078 structure
CAS No.
1254205-52-1
Chemical Name:
RQ-00203078
Synonyms
CS-1528;RQ-00203078;RQ-00203078 >=98% (HPLC);RQ-00203078;RQ 00203078;RQ00203078.;4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid;4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[4-(trifluoromethoxy)phenyl]methyl})sulfamoyl}benzoic acid;4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid;Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]-;Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol
CBNumber:
CB93040792
Molecular Formula:
C21H13ClF6N2O5S
Molecular Weight:
554.85
MDL Number:
MFCD29049510
MOL File:
1254205-52-1.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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RQ-00203078 Properties

Boiling point 602.0±65.0 °C(Predicted)
Density 1.588±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥27.25 mg/mL in EtOH
form solid
pka 3.39±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

RQ-00203078 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19075 RQ-00203078 ≥98% 1254205-52-1 1mg $32 2024-03-01 Buy
Cayman Chemical 19075 RQ-00203078 ≥98% 1254205-52-1 5mg $122 2024-03-01 Buy
Cayman Chemical 19075 RQ-00203078 ≥98% 1254205-52-1 10mg $199 2024-03-01 Buy
Tocris 5388 RQ00203078 ≥98%(HPLC) 1254205-52-1 10 $208 2021-12-16 Buy
Tocris 5388 RQ00203078 ≥98%(HPLC) 1254205-52-1 50 $870 2021-12-16 Buy
Product number Packaging Price Buy
19075 1mg $32 Buy
19075 5mg $122 Buy
19075 10mg $199 Buy
5388 10 $208 Buy
5388 50 $870 Buy

RQ-00203078 Chemical Properties,Uses,Production

Description

RQ-00203078 is a selective antagonist of transient receptor potential melastatin 8 (TRPM8; IC50s = 8.3 and 5.8 nM in human and rat, respectively), while having little inhibitory action against TRPV1 (IC50 > 30 μM), TRPA1 (IC50 > 10 μM), TRPV4 (IC50 = 10 μM), or TRPM2 channels (IC50 > 10 μM). It attenuates icilin-induced wet-dog shakes in rats (ED50 = 0.65 mg/kg) after oral administration. RQ-00203078 has been shown to reduce HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. TRPM8, a member of the TRP melastatin subgroup, plays a role in cold hyperalgesia and cold allodynia caused by disease conditions such as chemotherapy-induced peripheral neuropathy, diabetic neuropathy, migraine, and overactive bladder. It is also known to be involved in the tumor progression of certain carcinomas.

Uses

RQ 00203078 is a selective and orally active TRPM8 antagonist.

in vitro

in the menthol-induced calcium influx assay, rq-00203078 is a novel and highly potent trpm8 antagonist with human and rat ic50 values of 8.3 nm and 5.8 nm, respectively. rq-00203078 was highly selective over other trp channels [1].

in vivo

rq-00203078 demonstrated excellent activity in vivo in a dose dependent manner with an ed50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration [1].

IC 50

8.3 and 5.8 nm for htrpm8 and rtrpm8, respectively

storage

Store at +4°C

References

[1] ohmi m, shishido y, inoue t, ando k, fujiuchi a, yamada a, watanabe s, kawamura k. identification of a novel 2-pyridyl-benzensulfonamide derivative, rq-00203078, as a selective and orally active trpm8 antagonist. bioorg med chem lett. 2014 dec 1;24(23):5364-8.

RQ-00203078 Preparation Products And Raw materials

Raw materials

Preparation Products

RQ-00203078 Suppliers

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2992 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Rechem science Co., Ltd. 58

View Lastest Price from RQ-00203078 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RQ-00203078 pictures 2024-11-19 RQ-00203078
1254205-52-1
 US $43.00-126.00 / mg 99.17% 10g TargetMol Chemicals Inc.
RQ-00203078 pictures 2019-12-31 RQ-00203078
1254205-52-1
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
RQ-00203078 pictures 2019-12-31 RQ-00203078
1254205-52-1
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • RQ-00203078 pictures
  • RQ-00203078
    1254205-52-1
  • US $43.00-126.00 / mg
  • 99.17%
  • TargetMol Chemicals Inc.
  • RQ-00203078 pictures
  • RQ-00203078
    1254205-52-1
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co
  • RQ-00203078 pictures
  • RQ-00203078
    1254205-52-1
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

RQ-00203078 Spectrum

RQ-00203078(1254205-52-1)1HNMR
RQ-00203078 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid RQ-00203078;RQ 00203078;RQ00203078. CS-1528 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]- RQ-00203078 >=98% (HPLC) Transient receptor potential channels,Ca2+,TRPM8,RQ00203078,TRP Channel,migration,inhibit,Inhibitor,RQ 00203078,RQ-00203078,oral,invasion,menthol 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[4-(trifluoromethoxy)phenyl]methyl})sulfamoyl}benzoic acid 1254205-52-1 C21H13ClF6N2O5S Inhibitors