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LMI070

LMI070 Structure
LMI070 structure
CAS No.
1562338-42-4
Chemical Name:
LMI070
Synonyms
Branaplam;LMI070;NVS-SM1;LMI070 (NVS-SM1);NVS-SM1; LMI-070;;Branaplam (LMI070);NVS-SM1, Branaplam;LMI070 (Branaplam);LMI 070;LMI-070;LMI070;Branaplam, 10 mM in DMSO
CBNumber:
CB93053903
Molecular Formula:
C22H27N5O2
Molecular Weight:
393.48
MDL Number:
MFCD29472288
MOL File:
1562338-42-4.mol
Last updated:2025-04-18 09:53:10
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LMI070 Properties

Boiling point 660.0±55.0 °C(Predicted)
Density 1.171±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:3.0(Max Conc. mg/mL);7.62(Max Conc. mM)
form A crystalline solid
pka 7.84±0.40(Predicted)
color White to yellow
FDA UNII P12R69543A

LMI070 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26757 LMI070 1562338-42-4 1mg $44 2024-03-01 Buy
Cayman Chemical 26757 LMI070 1562338-42-4 25mg $796 2024-03-01 Buy
Cayman Chemical 26757 LMI070 1562338-42-4 5mg $202 2024-03-01 Buy
Cayman Chemical 26757 LMI070 1562338-42-4 10mg $363 2024-03-01 Buy
ChemScene CS-5319 Branaplam 99.67% 1562338-42-4 50mg $490 2021-12-16 Buy
Product number Packaging Price Buy
26757 1mg $44 Buy
26757 25mg $796 Buy
26757 5mg $202 Buy
26757 10mg $363 Buy
CS-5319 50mg $490 Buy

LMI070 Chemical Properties,Uses,Production

Uses

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2].

in vivo

Branaplam (LMI070; NVS-SM1; 3, 10, 30 mg/kg; oral) produces dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord[1].
? Branaplam (1 mg/kg of IV; 3 mg/kg of PO) has a CL of 25 mL/min/kg and an AUC of 3.03 μM?h[2].
? A single Branaplam (oral; 30 mg/kg) results in significant and durable SMN protein elevation in brain for up to 160 hours in C/+ mice[1].
? Branaplam (oral; 0.03, 0.1, 0.3, 1, 3 mg/kg) improves body weight and extendes lifespan in n SMNΔ7 mice[1].

Animal Model:C/+ SMA mouse model[1]
Dosage:3, 10, 30 mg/kg
Administration:Oral
Result:Produced dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord.
Animal Model:Male Sprague-Dawley rat[2]
Dosage:1 mg/kg (IV);3 mg/kg (PO) (Pharmacokinetic Analysis)
Administration:IV or PO
Result:Had a CL of 25 mL/min/kg and an AUC of 3.03 μM?h.

References

[1] Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice. Nat Chem Biol. 2015 Jul;11(7):511-517. DOI:10.1038/nchembio.1837
[2] Cheung AK, et al. Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA). J Med Chem. 2018 Dec 27;61(24):11021-11036. DOI:10.1021/acs.jmedchem.8b01291

LMI070 synthesis

13659-23-9
1562338-42-4
Synthesis of LMI070 from 2-Bromo-5-chlorophenol

LMI070 Preparation Products And Raw materials

Raw materials

1-Boc-pyrazole-4-boronic acid pinacol ester 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Bromo-5-chlorophenol 3-chloro-6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazine 2,2,6,6-Tetramethyl-4-piperidinol

Preparation Products

LMI070 Suppliers

Global( 79)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32200 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38636 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from LMI070 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Branaplam pictures 2024-11-19 Branaplam
1562338-42-4
 US $42.00-98.00 / mg 99.4% 10g TargetMol Chemicals Inc.
  • Branaplam pictures
  • Branaplam
    1562338-42-4
  • US $42.00-98.00 / mg
  • 99.4%
  • TargetMol Chemicals Inc.

1562338-42-4(LMI070)Related Search:

Infigratinib N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine NVS-PAK1-1 NVP-BSK805 NVP BGJ398 phosphate
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide NVP-CGM097

1of2

LMI070 NVS-SM1 NVS-SM1, Branaplam NVS-SM1; LMI-070; LMI070 (Branaplam) LMI070 (NVS-SM1) 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol LMI 070;LMI-070;LMI070 Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]- Branaplam (LMI070) Branaplam SMN2,SMA,inhibit,SMN,DNA/RNA Synthesis,Inhibitor,hERG,atrophy,Potassium Channel,neuron-2,motor,KcsA,gene,orally,LMI070,splicing,LMI-070,spinal,survival,Branaplam,muscular Branaplam, 10 mM in DMSO 1562338-42-4