CREB inhibitor (666-15)
- CAS No.
- 1433286-70-4
- Chemical Name:
- CREB inhibitor (666-15)
- Synonyms
- 666-15;compound3i;CREB 666-15;CREB inhibitor;compound3i(666-15);CREB inhibitor (666-15);breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor;3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
- CBNumber:
- CB93069852
- Molecular Formula:
- C33H31Cl2N3O5
- Molecular Weight:
- 620.53
- MDL Number:
- MFCD30182343
- MOL File:
- 1433286-70-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
CREB inhibitor (666-15) price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A616443 | 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride | 1433286-70-4 | 1mg | $95 | 2021-12-16 | Buy |
| TRC | A616443 | 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamideHydrochloride | 1433286-70-4 | 5mg | $400 | 2021-12-16 | Buy |
| ChemScene | CS-6499 | CREB inhibitor (666-15) 99.63% | 1433286-70-4 | 25mg | $552 | 2021-12-16 | Buy |
| ChemScene | CS-6499 | CREB inhibitor (666-15) 99.63% | 1433286-70-4 | 50mg | $996 | 2021-12-16 | Buy |
| ChemScene | CS-6499 | CREB inhibitor (666-15) 99.63% | 1433286-70-4 | 5mg | $156 | 2021-12-16 | Buy |
CREB inhibitor (666-15) Chemical Properties,Uses,Production
Uses
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent.
Biological Activity
CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells.
in vitro
666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions.
in vivo
In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated.
target
| Target | Value |
| CREB () | 81 nM |
storage
Desiccate at RT
CREB inhibitor (666-15) Preparation Products And Raw materials
Raw materials
Preparation Products
CREB inhibitor (666-15) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai XingMo Biotechnology Co., Ltd. | 13524779951 | 2075692521@qq.com | China | 310 | 55 |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10004 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8019 | 62 |