1361-50-8
- CAS No.
- 1361-51-9
- Chemical Name:
- 1361-50-8
- Synonyms
- Taxine B;1361-50-8;Valine Impurity 64;Benzenepropanoic acid, β-(dimethylamino)-, (3S,4aR,5S,6R,11R,12R,12aR)-11-(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-5,6,12-trihydroxy-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanobenzocyclodecen-3-yl ester, (βS)-
- CBNumber:
- CB93076485
- Molecular Formula:
- C33H45NO8
- Molecular Weight:
- 583.7123
- MDL Number:
- MOL File:
- 1361-51-9.mol
Melting point | l13-5°C (approx.) |
---|---|
Boiling point | 676.9±55.0 °C(Predicted) |
Density | 1.25±0.1 g/cm3(Predicted) |
solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 12.63±0.70(Predicted) |
color | White to Off-White |
Stability | Hygroscopic |
FDA UNII | CEB5005PDD |
1361-50-8 Chemical Properties,Uses,Production
Description
A constituent of Taxus baccata, this alkaloid is amorphous and has [α]20D + 119° (CHC13). The hydrochloride is also amorphous with no definite melting point. The nitrate, however, can be crystallized from Et20-isopropanol, m.p. 190°C. The base yields a diacetyl derivative which, although amorphous when obtained from aqueous solution, m.p. 92°C, forms colourless crystals from EtOH, m.p. 161.5°C. This latter base has [α]20Do + 106.7° (c 2.0, CHC1 3) and gives a crystalline hydrochloride from EtOH containing solvent of crystallization, m.p. 168-l70°C; nitrate as colourless needles or plates from EtOH, m.p. 141.5°C and the methiodide, m.p. 197°C. The structure of the alkaloid is that of Taxine I (q.v.) minus two acetyl groups.
Uses
Taxine B is a toxic pyrrolizidine alkaloid obtained from rhodadendron and ragwort plants decomposition. An impurity in the biosynthesis of Paclitaxel (P132500)
References
Harrison, Scrowston, Lythgoe., 1. Chern. Soc., C, 1933 (1966)
1361-50-8 Preparation Products And Raw materials
Raw materials
Preparation Products
1361-50-8 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18018 | 56 |
Chengdu Push Bio-Technology Co., Ltd. | 18080489829 | 3004654993@qq.com | China | 9209 | 58 |
guoyungurui | 18162595016 | 3287908757@qq.com | China | 10012 | 58 |
Supplier | Advantage |
---|---|
ChemStrong Scientific Co.,Ltd | 56 |
Chengdu Push Bio-Technology Co., Ltd. | 58 |
guoyungurui | 58 |