trans-ACUB
- CAS No.
- 885012-33-9
- Chemical Name:
- trans-ACUB
- Synonyms
- t-AUCB;trans-AUCB;trans-ACUB;trans-4-(4-[3-Adamantan-1-yl-ureido]-cyclohexyloxy)-benzoic acid;4-(((trans-4-(3-(Adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid;4-(((1R,4r)-4-(3-((3S,5S,7S)-adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid;Benzoic acid, 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-;epoxide,anti-glioma,transAUCB,hydrolase,activity,orally,trans-AUCB,sEH,trans AUCB,active,Inhibitor,inhibit,soluble,Epoxide Hydrolase
- CBNumber:
- CB93124324
- Molecular Formula:
- C24H32N2O4
- Molecular Weight:
- 412.52
- MDL Number:
- MFCD18633310
- MOL File:
- 885012-33-9.mol
trans-ACUB price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16568 | trans-AUCB ≥90% | 885012-33-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16568 | trans-AUCB ≥90% | 885012-33-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 16568 | trans-AUCB ≥90% | 885012-33-9 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 16568 | trans-AUCB ≥90% | 885012-33-9 | 50mg | $911 | 2024-03-01 | Buy |
| TRC | A192200 | trans-ACUB | 885012-33-9 | 1mg | $55 | 2021-12-16 | Buy |
trans-ACUB Chemical Properties,Uses,Production
Uses
trans-ACUB is a potent inhibitor of soluble epoxide hydrolase (sEH) which is known to convert epoxides to their corresponding diols. Inhibitors of sEH act as anti-inflammatory, anti-hypertensive and cardioprotective agents.
Biological Activity
trans-aucb is a potent inhibitor of soluble epoxide hydrolase (seh).soluble epoxide hydrolase (seh) can convert epoxides to their corresponding diols. inhibitors of seh have anti-hypertensive, anti-inflammatory, neuroprotective, and cardioprotective effects.
in vitro
a previous study showed that the pretreatment with dapt could substantially potentiate the growth inhibition caused by t-aucb in u251 and u87 cells. moreover, the pretreatment with dapt markedly increased t-aucb-induced apoptosis of u251 and u87 cells. moreover, t-aucb alone did not obviously affect caspase-3 activity in the cells, but t-aucb plus dapt pretreatment caused significant increase of caspase-3 activity. in addition, the pretreatment with dapt was able to completely block t-aucb-induced phosphorylation of p38 mapk, mapkapk2 and hsp27 in the cells [1].
in vivo
a previous animal study was conducted to investigate the effects of acute seh inhibition by t-aucb on infarct volume, functional outcome, and changes in cerebral blood flow (cbf) in a rat model of ischemic stroke. it was found that t-aucb could significantly reduce cortical infarct volume by 35%, elevate cumulative epoxyeicosatrienoic acids-to-dihydroxyeicosatrienoic acids ratio in brain cortex by twofold, and improve functional outcome in arm-flexion test when compared with that of the vehicle-treated group [2].
IC 50
0.5 nm
References
[1] li jy, li rj, wang hd. γ-secretase inhibitor dapt sensitizes t-aucb-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 mapk/mapkapk2/hsp27 pathway. acta pharmacol sin. 2014 jun;35(6):825-31.
[2] shaik js, ahmad m, li w, rose me, foley lm, hitchens tk, graham sh, hwang sh, hammock bd, poloyac sm. soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. am j physiol heart circ physiol. 2013 dec 1;305(11):h1605-13.
trans-ACUB Preparation Products And Raw materials
Raw materials
Preparation Products
trans-ACUB Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. | 021-58521787 17701827760 | starpharmsh@gmail.com | China | 208 | 58 |
| TaiChem Taizhou Limited | 052386810091 | zcwy9518@yeah.net | China | 3899 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7295 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
| Jiangsu yize medical technology co. LTD | 18550739526 | 23903480@qq.com | China | 5840 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |