ONO-4059 (hydrochloride)
- CAS No.
- 1439901-97-9
- Chemical Name:
- ONO-4059 (hydrochloride)
- Synonyms
- ON 0459;ON-0459;ONO-WG-307;ONO-4059 HCl;ON 0459;ON-0459;Tirabrutinib HCl;ONO-4059(HCl salt);ONO-4059 (GS-4059);GS-4059 (hydrochloride);ONO-4059 (hydrochloride)
- CBNumber:
- CB93126702
- Molecular Formula:
- C25H23ClN6O3
- Molecular Weight:
- 490.95
- MDL Number:
- MFCD30187521
- MOL File:
- 1439901-97-9.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| FDA UNII | U374135N48 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 | |||||||||
| NFPA 704 |
|
ONO-4059 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5637 | Tirabrutinib(hydrochloride) 98.80% | 1439901-97-9 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-5637 | Tirabrutinib(hydrochloride) 98.80% | 1439901-97-9 | 10mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-5637 | Tirabrutinib(hydrochloride) 98.80% | 1439901-97-9 | 25mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-5637 | Tirabrutinib(hydrochloride) 98.80% | 1439901-97-9 | 50mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-5637 | Tirabrutinib(hydrochloride) 98.80% | 1439901-97-9 | 100mg | $450 | 2021-12-16 | Buy |
ONO-4059 (hydrochloride) Chemical Properties,Uses,Production
Uses
ONO-4059 hydrochloride is a potent orally active BTK (Bruton's tyrosine kinase) inhibitor, IC50: 2.2nM.It is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration,it covalently binds to BTK within B cells,thereby preventing B-cell receptor signaling and impeding B-cell development.
Biological Activity
Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with IC50 of 2.2 nM.
in vitro
Compared with Lck, Fyn, LynA, ONO-4059 is more selective for BTK, and only inhibits anti-IgM-induced B cell activation in a concentration-dependent manner, but not anti-CD3/CD28-induced Activation of human PBMCs to T lymphocytes. ONO/GS-4059 inhibited cell proliferation in some malignant B cells, but also in the nanomolar concentration range, induced the classical apoptotic response of TMD8 cells.
in vivo
In the CIA mouse model, ONO-4059 exerted its curative effect by inhibiting the production of inflammatory chemokines and cytokines such as IL-6, IL-8, TNFalpha, etc. in monocytes, accompanied by cartilage erosion, bone damage, vascular Recession of nebula formation. In preclinical animal models and clinical CLL and NHL patients, ONO-4059 has antitumor activity, good safety and long-lasting efficacy.
target
| Target | Value |
| BTK | 2.2 nM |
ONO-4059 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2141 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 981 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from ONO-4059 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-02-25 | ONO4059 hydrochloride
1439901-97-9
|
US $9.00 / KG | 1KG | 99% | 10KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | ONO4059 hydrochloride
1439901-97-9
|
US $9.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | ONO4059 hydrochloride
1439901-97-9
|
US $9.00 / KG | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- ONO4059 hydrochloride
1439901-97-9
- US $9.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- ONO4059 hydrochloride
1439901-97-9
- US $9.00 / KG
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- ONO4059 hydrochloride
1439901-97-9
- US $9.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd