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AS-2444697

AS-2444697 structure

CAS No.: 1287665-60-4

Chemical Name:: AS-2444697

Synonyms: AS-244469;AS-2444697;AS-2444697 HC;AS-2444697 HCl;AS2444697 >=98% (HPLC);AS-2444697 (hydrochloride);FGNHLIIFEDYNFZ-UHFFFAOYSA-N;N-(3-CARBAMOYL-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-PYRAZOL-4-YL)-2-(2-METHYLPYRIDIN-4-YL)OXAZOLE-4-CARBOXAMIDE HCL;N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride;N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

CBNumber:: CB93133027

Molecular Formula:: C19H21ClN6O4

Molecular Weight:: 432.86084

MDL Number:: MFCD30182294

MOL File:: 1287665-60-4.mol

Last updated:2023-06-30 15:45:59

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AS-2444697 Properties

storage temp.	2-8°C
solubility	DMSO:16.83(Max Conc. mg/mL);38.88(Max Conc. mM)
form	powder
color	white to beige

AS-2444697 price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1643	AS2444697 ≥98% (HPLC)	1287665-60-4	5MG	$131	2023-06-20	Buy
Sigma-Aldrich	SML1643	AS2444697 ≥98% (HPLC)	1287665-60-4	25MG	$424	2023-06-20	Buy
Cayman Chemical	29505	AS-2444697 (hydrochloride)	1287665-60-4	1mg	$34	2024-03-01	Buy
Cayman Chemical	29505	AS-2444697 (hydrochloride)	1287665-60-4	10mg	$249	2024-03-01	Buy
Cayman Chemical	29505	AS-2444697 (hydrochloride)	1287665-60-4	5mg	$133	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1643	5MG	$131	Buy
SML1643	25MG	$424	Buy
29505	1mg	$34	Buy
29505	10mg	$249	Buy
29505	5mg	$133	Buy

AS-2444697 Chemical Properties,Uses,Production

Description

AS-2444697 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4; IC₅₀ = 21 nM). It is greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3. AS-2444697 inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC₅₀s = 250 and 47 nM, respectively). It is efficacious in rat models of adjuvant- and collagen-induced arthritis (ED₅₀s = 2.7 and 1.6 mg/kg, respectively). AS-2444697 (0.3-3 mg/kg, twice daily) reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and chemokine (C-C motif) ligand 2 (CCL2) without affecting blood pressure in the 5/6 nephrectomized rat model of chronic kidney disease.

Uses

AS2444697 has been used as an interleukin-1R-associated kinase 4 (IRAK4) inhibitor to study the role of interleukin (IL)-1/IL-33 signaling in the development of endometriosis using a mouse model of endometriosis. It has also been used to study its dose-dependent effect on the C-X-C motif chemokine ligand 8 (CXCL8) gene expression

Biochem/physiol Actions

AS2444697 is a potent and selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4) that suppresses the progression of chronic renal failure via anti-inflammatory action.

storage

Desiccate at RT

AS-2444697 Preparation Products And Raw materials

Raw materials

Preparation Products

AS-2444697 Suppliers

Global( 45)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18478	58
Changsha Fuzhen Biotechnology Co.，LTD	18670069958 18670069958	3062105966@qq.com	China	3262	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4574	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Changzhou Bojia Biomedical Technology Co., Ltd.	58
Changsha Fuzhen Biotechnology Co.，LTD	58
Sigma-Aldrich	80
Shanghai Lollane Biological Technology Co.,Ltd.	55

AS-244469 AS-2444697 N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride N-(3-CARBAMOYL-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-PYRAZOL-4-YL)-2-(2-METHYLPYRIDIN-4-YL)OXAZOLE-4-CARBOXAMIDE HCL 4-Oxazolecarboxamide, N-[3-(aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-, hydrochloride (1:1) AS-2444697 HCl FGNHLIIFEDYNFZ-UHFFFAOYSA-N N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride AS-2444697 (hydrochloride) AS2444697 >=98% (HPLC) AS-2444697 HC IL-1R associated kinase,IRAK-4,anti-inflammatory,IRAK,AS-2444697,inhibit,AS2444697,AS 2444697,renoprotective,Inhibitor,Interleukin-1 receptor associated kinase 1287665-60-4