AS-2444697
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- $34 - $1735
- Product name: AS-2444697
- CAS: 1287665-60-4
- MF: C19H21ClN6O4
- MW: 432.86084
- EINECS:-0
- MDL Number:MFCD30182294
- Synonyms:AS-2444697;N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride;AS-244469;N-(3-CARBAMOYL-1-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-PYRAZOL-4-YL)-2-(2-METHYLPYRIDIN-4-YL)OXAZOLE-4-CARBOXAMIDE HCL;4-Oxazolecarboxamide, N-[3-(aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-, hydrochloride (1:1);AS-2444697 HCl;FGNHLIIFEDYNFZ-UHFFFAOYSA-N;N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
11 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5mg
- 50
- 1mg
- 10mg
- 10
- 25MG
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number4233EF
- Product descriptionAS-2444697HCl
- Packaging5mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4233EF
- Product descriptionAS-2444697HCl
- Packaging10mg
- Price$374
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29505
- Product descriptionAS-2444697 (hydrochloride)
- Packaging1mg
- Price$34
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29505
- Product descriptionAS-2444697 (hydrochloride)
- Packaging5mg
- Price$133
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29505
- Product descriptionAS-2444697 (hydrochloride)
- Packaging10mg
- Price$249
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1643
- Product descriptionAS2444697 ≥98% (HPLC)
- Packaging5MG
- Price$131
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1643
- Product descriptionAS2444697 ≥98% (HPLC)
- Packaging25MG
- Price$424
- Updated2023-06-20
- Buy
- ManufacturerTocris
- Product number5430
- Product descriptionAS2444697 ≥98%(HPLC)
- Packaging10
- Price$257
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5430
- Product descriptionAS2444697 ≥98%(HPLC)
- Packaging50
- Price$1081
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA779985
- Product descriptionAS2444697
- Packaging50mg
- Price$965
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA779985
- Product descriptionAS2444697
- Packaging100mg
- Price$1735
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4233EF | AS-2444697HCl | 5mg | $245 | 2021-12-16 | Buy |
| AK Scientific | 4233EF | AS-2444697HCl | 10mg | $374 | 2021-12-16 | Buy |
| Cayman Chemical | 29505 | AS-2444697 (hydrochloride) | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 29505 | AS-2444697 (hydrochloride) | 5mg | $133 | 2024-03-01 | Buy |
| Cayman Chemical | 29505 | AS-2444697 (hydrochloride) | 10mg | $249 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1643 | AS2444697 ≥98% (HPLC) | 5MG | $131 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1643 | AS2444697 ≥98% (HPLC) | 25MG | $424 | 2023-06-20 | Buy |
| Tocris | 5430 | AS2444697 ≥98%(HPLC) | 10 | $257 | 2021-12-16 | Buy |
| Tocris | 5430 | AS2444697 ≥98%(HPLC) | 50 | $1081 | 2021-12-16 | Buy |
| TRC | A779985 | AS2444697 | 50mg | $965 | 2021-12-16 | Buy |
| TRC | A779985 | AS2444697 | 100mg | $1735 | 2021-12-16 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO:16.83(Max Conc. mg/mL);38.88(Max Conc. mM)
form :powder
color :white to beige
solubility :DMSO:16.83(Max Conc. mg/mL);38.88(Max Conc. mM)
form :powder
color :white to beige
Safety Information
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Description
AS-2444697 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4; IC50 = 21 nM). It is greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3. AS-2444697 inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC50s = 250 and 47 nM, respectively). It is efficacious in rat models of adjuvant- and collagen-induced arthritis (ED50s = 2.7 and 1.6 mg/kg, respectively). AS-2444697 (0.3-3 mg/kg, twice daily) reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and chemokine (C-C motif) ligand 2 (CCL2) without affecting blood pressure in the 5/6 nephrectomized rat model of chronic kidney disease.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
TargetMol Chemicals Inc.
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Changzhou Bojia Biomedical Technology Co., Ltd.
Changsha Fuzhen Biotechnology Co.，LTD
Sigma-Aldrich
Shanghai Lollane Biological Technology Co.,Ltd.