5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
- CAS No.
- 566-26-7
- Chemical Name:
- 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
- Synonyms
- 7alpha-Cholesterol;7α-Hydroxy Cholesterol;Cholest-5-En-3Β,7Α-Diol;Cholesterol Impurity 28;5-CHOLESTEN-3β, 7α-DIOL;7-ALPHA-HYDROXYCHOLESTEROL;7a-Hydroxycholest-5-en-3ol;7-alfa-Hydroxy-Cholesterol;3β,7α-Dihydroxycholest-5-ene;(3,7a)-Cholest-5-ene-3,7-diol
- CBNumber:
- CB9321715
- Molecular Formula:
- C27H46O2
- Molecular Weight:
- 402.66
- MDL Number:
- MFCD00201416
- MOL File:
- 566-26-7.mol
| Melting point | 168-170°C |
|---|---|
| Boiling point | 515.3±38.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Soluble in DMSO or in Ethanol. |
| form | solid |
| pka | 14.11±0.70(Predicted) |
| color | White or pale yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | 95D0I22I0V |
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H917990 | 7α-HydroxyCholesterol | 566-26-7 | 5mg | $305 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0005077 | CHOLEST-5-EN-3-BETA-7-ALPHA-DIOL 95.00% | 566-26-7 | 5MG | $497.13 | 2021-12-16 | Buy |
| IsoSciences | 13410 | 7α-Hydroxycholesterol ≥98% | 566-26-7 | 1mg | $195 | 2021-12-16 | Buy |
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties,Uses,Production
Description
7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4
Chemical Properties
White Solid
Uses
Secondary metabolite of Cholesterol.
Definition
ChEBI: The 7alpha-hydroxy derivative of cholesterol.
References
1) Duane and Javitt (2002),?Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med.,?139?109 2) Kim?et al.?(2015)?7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun.,?467?879 3) Kim?et al.?(2014)?27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol.,?274?462 4) Saito and Noguchi (2014)?7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun.,?446?741
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94717 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
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