3-Chloropropiophenone
- CAS No.
- 936-59-4
- Chemical Name:
- 3-Chloropropiophenone
- Synonyms
- 3-chloro-1-phenylpropan-1-one;3-CHLORO-1-PHENYL-1-PROPANONE;1-Propanone, 3-chloro-1-phenyl-;NSC 37238;NSC 227202;JACS-936-59-4;oropropiophenone;β-Chlorpropiophenon;á-chloropropiophenone;B-CHLOROPROPIOPHENONE
- CBNumber:
- CB9332104
- Molecular Formula:
- C9H9ClO
- Molecular Weight:
- 168.62
- MDL Number:
- MFCD00000990
- MOL File:
- 936-59-4.mol
- MSDS File:
- SDS
| Melting point | 48-50 °C(lit.) |
|---|---|
| Boiling point | 113-115 °C4 mm Hg(lit.) |
| Density | 1.1115 (rough estimate) |
| refractive index | 1.5350 (estimate) |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Water Solubility | Insoluble |
| BRN | 2043580 |
| Stability | Stable. Incompatible with strong bases, strong oxidizing agents. |
| CAS DataBase Reference | 936-59-4(CAS DataBase Reference) |
| FDA UNII | WBZ9Q23H2T |
| NIST Chemistry Reference | 1-Propanone, 3-chloro-1-phenyl-(936-59-4) |
| EPA Substance Registry System | 1-Propanone, 3-chloro-1-phenyl- (936-59-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29147000 | |||||||||
| NFPA 704 |
|
3-Chloropropiophenone price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 335614 | 3-Chloropropiophenone 98% | 936-59-4 | 50g | $69.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 335614 | 3-Chloropropiophenone 98% | 936-59-4 | 10g | $86.2 | 2024-03-01 | Buy |
| TCI Chemical | C0995 | 3-Chloropropiophenone >96.0%(GC) | 936-59-4 | 25g | $80 | 2024-03-01 | Buy |
| Alfa Aesar | A12290 | 3-Chloropropiophenone, 96% | 936-59-4 | 10g | $44.65 | 2024-03-01 | Buy |
| Alfa Aesar | A12290 | 3-Chloropropiophenone, 96% | 936-59-4 | 50g | $150.65 | 2024-03-01 | Buy |
3-Chloropropiophenone Chemical Properties,Uses,Production
Description
3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.
Chemical Properties
faintly yellow to tan crystalline powder
Uses
3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.
Uses
3-Chloropropiophenone is an Impurity of Fluoxetine (F597100).
Synthesis
Adding 3' -chlorobenzene acetone and levorotatory prolinol into 95% ethanol and stirring; cooling after the reaction liquid is wholly dissolved; adding potassium borohydride into the reaction solution in batches, and preserving heat after adding; heating the reaction solution for reflux reaction, and concentrating the reaction solution under reduced pressure; adding n-hexane into the reaction solution, heating, and adding active carbon for heat preservation and decoloration; filtering the reaction solution, leaching a filter cake by using normal hexane, and collecting filtrate; crystallizing and filtering the filtrate, leaching the filter cake once with n-hexane, and drying in vacuum to obtain 3-Chloropropiophenone.
3-Chloropropiophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lihe Pharm Technology（Wuhan）Co.,Ltd | +8618071517867 | info@lihepharma.com | China | 192 | 58 |
| Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd. | +86-86-02586819868 +8613913839793 | sales@jinchemical.com | China | 23 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20286 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 283 | 58 |
| Yantai Fenglu Fine Chemical Co. LTD | +8618315825527 | kevin.wang@xhtechgroup.com | China | 42 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
View Lastest Price from 3-Chloropropiophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 3-Chloropropiophenone
936-59-4
|
US $29.00 / g | 98.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | 3-Chloropropiophenone
936-59-4
|
US $29.00 / g | 98.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | 3-Chloropropiophenone
936-59-4
|
US $0.00 / g | 1g | 98% | 1kg | shandong perfect biotechnology co.ltd |
-
- 3-Chloropropiophenone
936-59-4
- US $29.00 / g
- 98.89%
- TargetMol Chemicals Inc.
-
- 3-Chloropropiophenone
936-59-4
- US $29.00 / g
- 98.89%
- TargetMol Chemicals Inc.
-
- 3-Chloropropiophenone
936-59-4
- US $0.00 / g
- 98%
- shandong perfect biotechnology co.ltd
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