ChemicalBook >> CAS DataBase List >>5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
![5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Structure](CAS/20180723/GIF/92285-87-5.gif)
- CAS No.
- 92285-87-5
- Chemical Name:
- 5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
- Synonyms
- L82-G17;L82 G17,L82G17;4-Chloro-5-(2-(3-hydroxybenzylidene)hydrazinyl)pyridazin-3(2H)-one;Benzaldehyde, 3-hydroxy-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone;5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
- CBNumber:
- CB94369445
- Molecular Formula:
- C11H9ClN4O2
- Molecular Weight:
- 264.67
- MDL Number:
- MOL File:
- 92285-87-5.mol
Last updated:2024-10-30 20:13:01
5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Chemical Properties,Uses,Production
Description
L82-G17 is a selective uncompetitive inhibitor of DNA ligase I (LigI).
Uses
3-Hydroxy-benzaldehyde (5-Chloro-6-oxo-1,6-dihydro-pyridazin-4-yl)-hydrazone can be used to determine the structure-activity relationships among DNA ligase inhibitors.
in vitro
Among the LigI-selective inhibitors, L82-G17 exhibited increased activity against and selectivity for LigI compared with L82. Notably. L82-G17 is an uncompetitive inhibitor of the third step of the ligation reaction, phosphodiester bond formation. Cells expressing LigI were more sensitive to L82-G17 than isogenic LIG1 null cells._x000D_ _x000D_ Reference: DNA Repair (Amst). 2017 Dec;60:29-39. https://pubmed.ncbi.nlm.nih.gov/29078112/
target
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor.
5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Preparation Products And Raw materials
Raw materials
Preparation Products
5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one Suppliers
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5-chloro-4-[(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one
L82-G17
L82 G17,L82G17
Benzaldehyde, 3-hydroxy-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone
4-Chloro-5-(2-(3-hydroxybenzylidene)hydrazinyl)pyridazin-3(2H)-one
92285-87-5