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CLP257

CAS No.
1181081-71-9
Chemical Name:
CLP257
Synonyms
CLP257;(Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one;(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone;4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)-;Inhibitor,post-translationally,hypersensitivity,plasma,Potassium Channel,neuropathic,antihyperalgesic,CLP 257,membrane,KcsA,mechanical,sensitivity,CLP-257,CLP257,KCC2,inhibit
CBNumber:
CB94667761
Molecular Formula:
C14H14FN3O2S
Molecular Weight:
307.34
MDL Number:
MFCD28166488
MOL File:
1181081-71-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

CLP257 Properties

Boiling point 473.3±55.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 20 mg/ml
pka 7.23±0.40(Predicted)
form powder
color white to yellow to light brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
NFPA 704
0
2 0

CLP257 price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1368 CLP257 ≥98% (HPLC) 1181081-71-9 5MG $129 2023-06-20 Buy
Sigma-Aldrich SML1368 CLP257 ≥98% (HPLC) 1181081-71-9 25MG $507 2023-06-20 Buy
Tocris 5242 CLP257 ≥98%(HPLC) 1181081-71-9 50 $878 2021-12-16 Buy
Tocris 5242 CLP257 ≥98%(HPLC) 1181081-71-9 10 $210 2021-12-16 Buy
Usbiological 255013 CLP 257 1181081-71-9 10mg $460 2021-12-16 Buy
Product number Packaging Price Buy
SML1368 5MG $129 Buy
SML1368 25MG $507 Buy
5242 50 $878 Buy
5242 10 $210 Buy
255013 10mg $460 Buy

CLP257 Chemical Properties,Uses,Production

Uses

CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.

Biochem/physiol Actions

CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

storage

Store at +4°C

CLP257 Preparation Products And Raw materials

Raw materials

Preparation Products

CLP257 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13913916777 info@chemlin.com.cn China 18079 64
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2993 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9854 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone CLP257 4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)- Inhibitor,post-translationally,hypersensitivity,plasma,Potassium Channel,neuropathic,antihyperalgesic,CLP 257,membrane,KcsA,mechanical,sensitivity,CLP-257,CLP257,KCC2,inhibit (Z)-5-(4-fluoro-2-hydroxybenzylidene)-2-(tetrahydropyridazin-1(2H)-yl)thiazol-4(5H)-one 1181081-71-9