8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one
- CAS No.
- 2006317-76-4
- Chemical Name:
- 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one
- Synonyms
- 8-Br-5-F-2,2-dimethyl-4H-1,3-benzodioxin-4-one;8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one;4H-1,3-Benzodioxin-4-one, 8-bromo-5-fluoro-2,2-dimethyl-;8-bromo-5-fluoro-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one
- CBNumber:
- CB94798195
- Molecular Formula:
- C10H8BrFO3
- Molecular Weight:
- 275.07
- MDL Number:
- MOL File:
- 2006317-76-4.mol
8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Chemical Properties,Uses,Production
Synthesis
3-bromo-6-fluoro-2-hydroxybenzoic acid (25 g, 106.38 mmol, 1 eq) was dissolved in a mixed solution of DMF (1.5 mL) and acetone (63.20 g, 1.09 mol, 80 mL, 10.23 eq). At 0°C, TFAA (151.00 g, 718.94 mmol, 100 mL, 6.76 eq) and TFA (10 mL) were added dropwise to the mixed solution. The temperature of the mixed solution was raised to 100°C and stirred for 12 hours. The mixed solution was poured into saturated Na2CO3(500 mL) and stirred for 10 minutes. Then extract with ethyl acetate (150 mL×2). The combined organic phases were washed with brine (15 mL x 2), dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The crude product after the residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=1/0 to 20/1) was washed with PE (40 mL), filtered and the filter cake was dried under reduced pressure to obtain 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one.
8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Jurong Coupling Biotechnology Co., Ltd. | 13656108824 | 278191416@qq.com | China | 427 | 58 |
Nanjing Asfam Pharmaceutical Technology Co., Ltd. | 025-58867862 18751812725 | sales@ace-pharm.com | China | 1995 | 58 |
Shanghai Gugang New Materials Technology Co. Ltd. | 021-51317962 | 296935822@qq.com | China | 974 | 58 |
Shanghai Minhan Pharmaceutical Technology Co., Ltd. | 176121882 | 2816925681@qq.com | China | 2885 | 58 |
Birdo (Shanghai) Medical Technology Co., Ltd. | 021-021-021-58099077-8102-8041-8041 18601625411 | sales@birdotech.com | China | 9366 | 58 |
Taizhou Nanfeng Pharmaceutical Research Institute | 18616377689 | nanfengdrug@163.com | China | 20566 | 58 |
Shanghai meikai technology co., ltd | 021-18721550-091 18721550091 | yangdong@pharma.com | China | 4123 | 58 |
Nanjing Pope Bio-tech R&D Co., Ltd | 025-87138562 18951783565 | sales@popebiotech.com | China | 1112 | 58 |
Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 39990 | 58 |