| Company Name: |
Nanjing Asfam Pharmaceutical Technology Co., Ltd.
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| Tel: |
025-58867862 18751812725 |
| Email: |
sales@ace-pharm.com |
| Products Intro: |
Product Name:8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one
CAS:2006317-76-4
Purity:95% HPLC Package:10g 100g 1kg 烦请询价
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| | 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Basic information |
| Product Name: | 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one | | Synonyms: | 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one;4H-1,3-Benzodioxin-4-one, 8-bromo-5-fluoro-2,2-dimethyl-;8-Br-5-F-2,2-dimethyl-4H-1,3-benzodioxin-4-one;8-bromo-5-fluoro-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one | | CAS: | 2006317-76-4 | | MF: | C10H8BrFO3 | | MW: | 275.07 | | EINECS: | | | Product Categories: | | | Mol File: | 2006317-76-4.mol | ![8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Structure](CAS/20200401/GIF/2006317-76-4.gif) |
| | 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Chemical Properties |
| Boiling point | 380.0±42.0 °C(Predicted) | | density | 1.583±0.06 g/cm3(Predicted) |
| | 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Usage And Synthesis |
| Synthesis | 3-bromo-6-fluoro-2-hydroxybenzoic acid (25 g, 106.38 mmol, 1 eq) was dissolved in a mixed solution of DMF (1.5 mL) and acetone (63.20 g, 1.09 mol, 80 mL, 10.23 eq). At 0°C, TFAA (151.00 g, 718.94 mmol, 100 mL, 6.76 eq) and TFA (10 mL) were added dropwise to the mixed solution. The temperature of the mixed solution was raised to 100°C and stirred for 12 hours. The mixed solution was poured into saturated Na2CO3(500 mL) and stirred for 10 minutes. Then extract with ethyl acetate (150 mL×2). The combined organic phases were washed with brine (15 mL x 2), dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The crude product after the residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=1/0 to 20/1) was washed with PE (40 mL), filtered and the filter cake was dried under reduced pressure to obtain 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one.
![8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one](/NewsImg/2023-10-26/6383391092495174443717389.jpg "8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one") |
| | 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Preparation Products And Raw materials |
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