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N-METHYLISATIN

N-METHYLISATIN structure

CAS No.: 2058-74-4

Chemical Name:: N-METHYLISATIN

Synonyms: OL-57;187287;NSC 42449;AKOS BC-1698;N-Methylsatin;1-METHYLISATIN;N-METHYLISATIN;1 METHYLISATINE;Methylisatintech;AKOS BBS-00000999

CBNumber:: CB9480285

Molecular Formula:: C9H7NO2

Molecular Weight:: 161.16

MDL Number:: MFCD00005812

MOL File:: 2058-74-4.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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N-METHYLISATIN Properties

Melting point	130-133 °C (lit.)
Boiling point	287.44°C (rough estimate)
Density	1.314
refractive index	1.5050 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	-2.41±0.20(Predicted)
form	Crystalline Powder
color	Orange to brownish
Water Solubility	Insoluble in water.
λmax	427nm(CH2Cl2)(lit.)
BRN	128280
CAS DataBase Reference	2058-74-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	CNV9DH4SXQ

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H315-H318-H335

Precautionary statements

P280-P301+P310+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Risk Statements

25-37/38-41

Safety Statements

26-39-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

NL7939000

HazardClass

IRRITANT

HS Code

29337900

Toxicity

mouse,LD50,intraperitoneal,685mg/kg (685mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Pharmaceutical Chemistry Journal Vol. 15, Pg. 858, 1981.

NFPA 704

	1
2		0

N-METHYLISATIN price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	183075	1-Methylisatin 97%	2058-74-4	1g	$41.6	2024-03-01	Buy
Sigma-Aldrich	183075	1-Methylisatin 97%	2058-74-4	10g	$82.4	2024-03-01	Buy
TCI Chemical	M2706	1-Methylisatin >98.0%(GC)	2058-74-4	1g	$31	2024-03-01	Buy
TCI Chemical	M2706	1-Methylisatin >98.0%(GC)	2058-74-4	5g	$111	2024-03-01	Buy
Alfa Aesar	A12942	1-Methylisatin, 97%	2058-74-4	1g	$35.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
183075	1g	$41.6	Buy
183075	10g	$82.4	Buy
M2706	1g	$31	Buy
M2706	5g	$111	Buy
A12942	1g	$35.65	Buy

N-METHYLISATIN Chemical Properties,Uses,Production

Chemical Properties

ORANGE TO BROWNISH CRYSTALLINE POWDER

Uses

Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
Reactant for regioselective preparation of spirocyclic oxindole-butenolides
Reactant for synthesis of spiro-oxindoles
Reactant for preparation of unsymmetrical oxindoles
Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents

Uses

1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s

General Description

The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations.

N-METHYLISATIN synthesis

Synthesis of N-METHYLISATIN from Methyl bromide and Isatin

N-METHYLISATIN Preparation Products And Raw materials

Raw materials

2-Butynamide, N-methyl-N-phenyl- 2-Propynamide, N-methyl-N-phenyl- 2-Propenamide,N-methyl-N,3-diphenyl- Acetamide, N-methyl-2-(methylphenylamino)- 2-Propynamide, N-methyl-N,3-diphenyl-

1-Methylindoline 4-Acetylbenzoic acid 1-METHYL-2-INDOLINONE Ethanone, 1-[2-(methylamino)phenyl]- (9CI) Isatin

1-benzyl-5-iodoindoline-2,3-dione 5-iodo-1-methylindoline-2,3-dione

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Preparation Products

2-Thiophenecarboxylic acid 5-METHYL-1,2,4-TRIAZINO[5,6-B]INDOLE-3-THIOL 1-METHYL-1H-INDOLE-2,3-DIONE 3-[N-(4-CHLOROPHENYL)HYDRAZONE] (7Z)-3-(4-fluorophenyl)-7-(1-methyl-2-oxoindol-3-ylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one

N-METHYLISATIN Suppliers

Global( 164)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17982	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5659	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
GLR Innovations	+91 9891111994	info@glrgroup.in	India	4535	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18148	58

Supplier	Advantage
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GLR Innovations	58
Hebei Weibang Biotechnology Co., Ltd	58

View Lastest Price from N-METHYLISATIN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	1-Methylisatin 97% 2058-74-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-02-01	N-METHYLISATIN 2058-74-4	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co

1-Methylisatin 97%
2058-74-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-METHYLISATIN
2058-74-4
US $1.00 / KG
99%
Career Henan Chemical Co

N-METHYLISATIN Spectrum

N-METHYLISATIN(2058-74-4)¹HNMR N-METHYLISATIN(2058-74-4)IR1 N-METHYLISATIN(2058-74-4)IR2 N-METHYLISATIN(2058-74-4)Raman

2058-74-4(N-METHYLISATIN)Related Search:

3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one 1-Methyl-1H-indole-3-carboxylic acid 1-Methylindole Ramosetron hydrochloride

Rasagiline Impurity 5 Mesylate 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one ramosetron 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride Rasagiline Impurity 3

3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one Ramosetron Impurity 13 N-[4,5,6,7-Tetrahydrobenzimidazole-5-yl)carbonyl] pyrrolidine sulfate 1-PHENYLISATIN 1-(Hydroxymethyl)indoline-2,3-dione

N-METHYLISATIN 1,5-DIMETHYLINDOLINE-2,3-DIONE 5-CHLORO-7-METHYLISATIN

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1-methylindoline-2,3-dione 1-Methyl-2,3-dihydro-1H-indole-2,3-dione OL-57 N-Methylindol-2,3-dione 1-Methylisatin,98% N-Methylindoline-2,3-dione 1-Methyl-1H-indole-2,3-dione, 1-Methylindolin-2,3-dione 1-Methylisatin 97+% 1-Methylisatin 97% NSC 42449 1H-Indole-2,3-dione, 1-methyl- (9CI) 1H-Indole-2,3-dione, 1-Methyl- Indole-2,3-dione, 1-methyl- Ramosetron Impurity 1 1-methyl-1h-indole-3-dione 1-methyl-indole-2,3-dione 1-methyl-indole-3-dione 1-METHYL-1H-INDOLE-2,3-DIONE 1 METHYLISATINE 1-METHYLISATIN N-METHYLISATIN TIMTEC-BB SBB006835 1-methyl-2,3-dihydroindole-2,3-dione Methylisatintech N-Methylsatin N-Methylisatin, tech. N-Methylisatin 98% AKOS BBS-00000999 AKOS BC-1698 187287 1-Methylisatin, 97%, for synthesis 1-Methylisatin > 1-Methylindoline-2,3-dione (Ramosetron Impurity) 2058-74-4 Indoles Heterocyclic Building Blocks Building Blocks Heterocycles Building Blocks Heterocyclic Building Blocks Indoles pharmacetical