B-HT 933 DIHYDROCHLORIDE
- CAS No.
- 36067-72-8
- Chemical Name:
- B-HT 933 DIHYDROCHLORIDE
- Synonyms
- b-ht933;Nsc310831;Azepexole hydrochloride;B-HT 933 (hydrochloride);Azepexole dihydrochloride;β2AR/M3-receptor agonist-1;B-HT 933 DIHYDROCHLORIDE SELECTIVE A2 AD RENORE;5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(dihydrochloride;5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(4,5-d)azepin-2-aminedihydrochloride;2-amino-6-ethyl-4,5,7,8-tetrahydro-6h-oxazolo(5,4-d)azepinedihydrochloride
- CBNumber:
- CB9496972
- Molecular Formula:
- C9H16ClN3O
- Molecular Weight:
- 217.7
- MDL Number:
- MFCD01529923
- MOL File:
- 36067-72-8.mol
| storage temp. | Desiccate at RT |
|---|---|
| solubility | H2O: >20 mg/mL |
| form | solid |
| color | white to off-white |
| FDA UNII | O596V52O42 |
B-HT 933 DIHYDROCHLORIDE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 10mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 25mg | $456 | 2024-03-01 | Buy |
| TRC | H671813 | B-HT933Dihydrochloride | 36067-72-8 | 25mg | $215 | 2021-12-16 | Buy |
B-HT 933 DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
B-HT 933 is an agonist of α2-adrenergic receptors (α2-ARs) with an EC50 value of 0.65 μM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine . B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.
Uses
B-HT 933 Dihydrochloride is a selective α2-adrenoceptor agonist and has less potent inhibitory effect on the sympathetic vasopressor responses in diabetic rats.
in vitro
b-ht 933, a selective α2-adrenoceptor agonist, contracts human subcutaneous resistance arteries by a mechanism largely dependent on the influx of extracellular ca2+, probably through voltage-operated calcium channels. this action involves a pertussis toxin-sensitive g protein, possibly gq [1].
in vivo
the dose-related effects of the selective α2-adrenoceptor agonist b-ht 933 on the body temperature of untreated and reserpine-treated mice were investigated. in untreated mice b-ht 933 induced a dose-related hypothermia. the highest dose of b-ht 933 elicited a marked hypothermia, whereas the maximal hypothermic effect of clonidine was less pronounced and reached a plateau at a dose of 0.5 mg/kg [2].
IC 50
0.44 μm
storage
Desiccate at RT
References
[1] n. a. parkinson & a.d. hughes. the mechanism of action of 1c2-adrenoceptors in human isolated subcutaneous resistance arteries. british journal of pharmacology (1995) 115, 1463-1468
[2] d. j. bill, i.e. hughes & r.j. stephens. the thermogenic actions of x2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic ac2-adrenoceptor mechanism. br. j. pharmacol. (1989), 96, 133-143
B-HT 933 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
B-HT 933 DIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | sales@ubiochem.com | China | 4297 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8617 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4871 | 58 |
View Lastest Price from B-HT 933 DIHYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | B-HT 933 dihydrochloride
36067-72-8
|
US $348.00-498.00 / mg | 10g | TargetMol Chemicals Inc. |
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- B-HT 933 dihydrochloride
36067-72-8
- US $348.00-498.00 / mg
- TargetMol Chemicals Inc.