Pinacidil
- CAS No.
- 85371-64-8
- Chemical Name:
- Pinacidil
- Synonyms
- Hndac;Pinacidil;Pinacidil Hydrate;Pinacidil USP/EP/BP;Pinacidil monohydrate (Pinacidil hydrate);Pinacidil monohydrate (Synonyms: Pinacidil hydrate);(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine;Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate;(±)-N-Cyano-N’-4-pyridinyl-N’’-(1,2,2-trimethylpropyl)guanidine monohydrate;Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)
- CBNumber:
- CB9498330
- Molecular Formula:
- C13H21N5O
- Molecular Weight:
- 263.35
- MDL Number:
- MFCD00242745
- MOL File:
- 85371-64-8.mol
- MSDS File:
- SDS
Melting point | 164-165° |
---|---|
storage temp. | RT |
solubility | ethanol: 14 mg/mL |
form | solid |
pka | pKa 空 (Uncertain) |
color | white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 85371-64-8(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 7B0ZZH8P2W |
ATC code | C02DG01 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 36 | |||||||||
WGK Germany | 3 | |||||||||
Toxicity | LD50 in mice, rats (mg/kg): 600, 570 orally (Petersen, 1978) | |||||||||
NFPA 704 |
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Pinacidil price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P154 | Pinacidil monohydrate powder | 85371-64-8 | 100mg | $152 | 2024-03-01 | Buy |
Sigma-Aldrich | P154 | Pinacidil monohydrate powder | 85371-64-8 | 1g | $901 | 2024-03-01 | Buy |
Cayman Chemical | 15416 | Pinacidil (hydrate) ≥98% | 85371-64-8 | 25mg | $29 | 2024-03-01 | Buy |
Cayman Chemical | 15416 | Pinacidil (hydrate) ≥98% | 85371-64-8 | 50mg | $54 | 2024-03-01 | Buy |
Sigma-Aldrich | P154 | Pinacidil monohydrate powder | 85371-64-8 | 500mg | $603 | 2024-03-01 | Buy |
Pinacidil Chemical Properties,Uses,Production
Description
Pinacidil is a peripheral vasodilator useful in the management of arterial hypertension of all degrees of seventy, usually in combination with a diuretic or beta-blocker. Preclinical evidence suggests that its hypotensive effect may be attributed to potassium channel activation.
Originator
Leo (Denmark)
Uses
cardiac stimulant
Uses
Pinacidil monohydrate has been used:
- in repolarization studies by infusing into left anterior descending artery (LAD)
- to induce ATP-sensitive K+ (KATP) current in ventricular myocytes for electrophysiological studies
- as a KATP opener to treat myocardial cells
Uses
Pinacidil Monohydrate is a K+ channel opener, used to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. Vasodilator. Antihypertensive agent.
Definition
ChEBI: Pinacidil is an organic molecular entity.
brand name
Pindac (Leo).
Biochem/physiol Actions
Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury.
References
1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17 2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Pharmacol. Exp. Therap., 275 681 3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5 4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796 5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428 6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7
Pinacidil Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5894 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49403 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7726 | 58 |
changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9740 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Pinacidil manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-11 | Pinacidil monohydrate
85371-64-8
|
US $1.90-1.90 / KG | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | ||
2020-05-12 | Pinacidil
85371-64-8
|
US $0.00-0.00 / KG | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | ||
2019-07-06 | Pinacidil
85371-64-8
|
US $1.00 / kg | 1kg | 95%-99% | 10kg | Career Henan Chemical Co |
- Pinacidil monohydrate
85371-64-8
- US $1.90-1.90 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
- Pinacidil
85371-64-8
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
- Pinacidil
85371-64-8
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co