Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>RIPK1-IN-7

RIPK1-IN-7

RIPK1-IN-7 Structure
RIPK1-IN-7 structure
CAS No.
2300982-44-7
Chemical Name:
RIPK1-IN-7
Synonyms
RIPK1-IN-7;RIPK1 inhibitor 7;1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one;Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]-;RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI
CBNumber:
CB95419833
Molecular Formula:
C25H22F3N5O2
Molecular Weight:
481.47
MDL Number:
MOL File:
2300982-44-7.mol
Last updated:2024-07-02 08:55:42
Request For Quotation

RIPK1-IN-7 Properties

Boiling point 724.8±60.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 62.5 mg/mL (129.81 mM); Water: < 0.1 mg/mL (insoluble)
form Solid
pka 5.76±0.30(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

RIPK1-IN-7 Chemical Properties,Uses,Production

Biological Activity

RIPK1-IN-7 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an IC50 of 11 nM. RIPK1-IN-7 has good anti-metastatic activity in an experimental B16 melanoma lung metastasis model.

in vitro

RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM.
It displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.

target

IC50: 11 nM (RIPK1)
Kd: 4 nM (RIPK1)

RIPK1-IN-7 Preparation Products And Raw materials

Raw materials

Preparation Products

RIPK1-IN-7 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 3320 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12308 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 29778 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 10015 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Raise Chemical Technology Co.,Ltd 55
Beijing Jin Ming Biotechnology Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Henan Alpha Chemical Co., Ltd. 58
RIPK1-IN-7 RIPK1 inhibitor 7 Ethanone, 1-[5-(4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethoxy)phenyl]- RIPK-1-IN-7,inhibit,TrkA,Mer,Receptor-interacting protein kinases,Flt4,Axl,TrkB,Inhibitor,RIP kinase,RIPK,TrkC,RIPK1 IN 7,RIPK1IN7,HRI 1-(5-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethoxy)phenyl)ethan-1-one 2300982-44-7