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SNIPER(BRD)-1

SNIPER(BRD)-1 Structure
SNIPER(BRD)-1 structure
CAS No.
2095244-54-3
Chemical Name:
SNIPER(BRD)-1
Synonyms
SNIPER(BRD)-1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-α-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,3,9-trimethyl-, (6S)-
CBNumber:
CB95540348
Molecular Formula:
C53H66ClN9O8S2
Molecular Weight:
1056.74
MDL Number:
MFCD32062729
MOL File:
2095244-54-3.mol
Last updated:2024-07-02 08:55:42
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SNIPER(BRD)-1 Properties

Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, stored under nitrogen
solubility DMSO : 100 mg/mL (94.63 mM; Need ultrasonic)
form Solid
pka 14.25±0.46(Predicted)
color Off-white to light yellow

SNIPER(BRD)-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0093305 SNIPER(BRD)-1 98.40% 2095244-54-3 1mg $800 2021-12-16 Buy
Product number Packaging Price Buy
CS-0093305 1mg $800 Buy

SNIPER(BRD)-1 Chemical Properties,Uses,Production

Biological Activity

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

References

[1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

SNIPER(BRD)-1 Preparation Products And Raw materials

Raw materials

Preparation Products

SNIPER(BRD)-1 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4475 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9282 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Fan De(Beijing) Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
RD International Technology Co., Limited 58
SNIPER(BRD)-1 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-α-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,3,9-trimethyl-, (6S)- 2095244-54-3