Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>SHS4121705

SHS4121705

SHS4121705 Structure
SHS4121705 structure
CAS No.
2379550-82-8
Chemical Name:
SHS4121705
Synonyms
SHS4121705;SHS4121705,SHS-4121705;6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one;[1,2,5]Oxadiazolo[3,4-b]pyrazin-5(3H)-one, 6-[[4-(trifluoromethoxy)phenyl]amino]-
CBNumber:
CB96198005
Molecular Formula:
C11H6F3N5O3
Molecular Weight:
313.19
MDL Number:
MOL File:
2379550-82-8.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

SHS4121705 Properties

Boiling point 338.3±52.0 °C(Predicted)
Density 1.81±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml
form A crystalline solid
pka -2.30±0.20(Predicted)

SHS4121705 Chemical Properties,Uses,Production

Biological Activity

SHS4121705 is an orally bioavailable mitochondrial uncoupler.1 It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).

References

1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020)

SHS4121705 Preparation Products And Raw materials

Raw materials

Preparation Products

SHS4121705 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5587 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
ChemeGen 中国 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
SHS4121705 SHS4121705,SHS-4121705 [1,2,5]Oxadiazolo[3,4-b]pyrazin-5(3H)-one, 6-[[4-(trifluoromethoxy)phenyl]amino]- 6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one 2379550-82-8