CONCANAMYCIN A
- CAS No.
- 80890-47-7
- Chemical Name:
- CONCANAMYCIN A
- Synonyms
- FOLIMYCIN;S-45A;A661-I;x4357b;NSC 674620;Canavalin A;Concanamycin;CONCANAMYCIN A;A,ConcanaMycin;Antibiotic S-45A
- CBNumber:
- CB9696475
- Molecular Formula:
- C46H75NO14
- Molecular Weight:
- 866.09
- MDL Number:
- MFCD00210037
- MOL File:
- 80890-47-7.mol
Melting point | 179-180℃ (dichloromethane ethanol ) |
---|---|
Boiling point | 966.4±65.0 °C(Predicted) |
Density | 1.20±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | Soluble in DMSO |
form | Lyophilized solid |
pka | 12.46±0.70(Predicted) |
color | White |
BRN | 3560277 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H300+H310+H330-H319 | |||||||||
Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338 | |||||||||
Hazard Codes | T+ | |||||||||
Risk Statements | 26/27/28-36 | |||||||||
Safety Statements | 26-36/37/39-45 | |||||||||
RIDADR | UN 3462 6.1/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | CB9732000 | |||||||||
F | 10-21 | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
HS Code | 2941900000 | |||||||||
NFPA 704 |
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CONCANAMYCIN A price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C9705 | Concanamycin A ≥70% (HPLC) | 80890-47-7 | 25μg | $193 | 2024-03-01 | Buy |
Sigma-Aldrich | C9705 | Concanamycin A ≥70% (HPLC) | 80890-47-7 | 0.1mg | $597 | 2024-03-01 | Buy |
Sigma-Aldrich | 27689 | Concanamycin A from Streptomyces sp., ≥80% (HPLC) | 80890-47-7 | 250μg | $1410 | 2023-06-20 | Buy |
Sigma-Aldrich | 344085 | Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). | 80890-47-7 | 10μg | $143 | 2022-05-15 | Buy |
Sigma-Aldrich | 27689 | Concanamycin A from | 80890-47-7 | 250ug | $1150 | 2021-12-16 | Buy |
CONCANAMYCIN A Chemical Properties,Uses,Production
Description
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
Uses
Concanamycin A has been used:
- as a lysosomal inhibitor in young and old fibroblasts
- as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
- as a lysosomal acidification blocker in HepG2 hepatocytes cells
Uses
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.
Definition
ChEBI: A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.
General Description
Chemical structure: macrolide
Biological Activity
Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
Biochem/physiol Actions
Concanamycin A (ConA) inhibits acidification of organelles and perforin-mediated cytotoxicity. It is a vacuolar-type v-ATPase inhibitor. ConA possesses antiprotozoal and antineoplastic properties. It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.
storage
Store at -20°C
References
1) Nishihara?et al.?(1995),?Specific inhibitors if vacuolar type H(+)-ATPases induce apoptotic cell death; Biochem. Biophys, Res. Commun.,?212?255 2) Hong?et al. (2006),?Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells; J. Pharmacol. Exp. Ther.,?319?672 3) Muroi?et al.?(1993),?Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus; Cell Struct. Function,?18?139 4) Cashikar and Hanson (1987),?A cell-based assay for CD63-containing extracellular vesicles; PLoS One,?14?e0220007 5) Gradzka?et al.?(2018),?Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes; Cell Death Dis.,?9?529
CONCANAMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7726 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-18791163155 +86-13119157289 | 13119157289@163.com | China | 2972 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11442 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 4554 | 62 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | meilunui@163.com | China | 4669 | 58 |