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Ginsenoside Rg3

Ginsenoside Rg3 Structure
Ginsenoside Rg3 structure
CAS No.
14197-60-5
Chemical Name:
Ginsenoside Rg3
Synonyms
Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
CBNumber:
CB9713141
Molecular Formula:
C42H72O13
Molecular Weight:
785.03
MDL Number:
MFCD06410950
MOL File:
14197-60-5.mol
MSDS File:
SDS
Last updated:2024-04-08 09:57:41
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Ginsenoside Rg3 Properties

Melting point 315-318°C
Boiling point 885.0±65.0 °C(Predicted)
Density 1.30
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
pka 12.85±0.70(Predicted)
form powder
color white to beige
optical activity [α]/D +10 to +20°, c = 1 in methanol
InChIKey RWXIFXNRCLMQCD-JBVRGBGGSA-N
CAS DataBase Reference 14197-60-5(CAS DataBase Reference)
FDA UNII 227D367Y57

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  LY9537300
HS Code  29389090
Toxicity mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
NFPA 704
0
2 0

Ginsenoside Rg3 price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0184 Ginsenoside Rg3 ≥98% (HPLC) 14197-60-5 5mg $128 2024-03-01 Buy
Sigma-Aldrich 64139 Ginsenoside Rg3 analytical standard 14197-60-5 10mg $396 2024-03-01 Buy
Cayman Chemical 15332 Ginsenoside Rg3 ≥95% 14197-60-5 5mg $32 2024-03-01 Buy
Cayman Chemical 15332 Ginsenoside Rg3 ≥95% 14197-60-5 10mg $57 2024-03-01 Buy
Sigma-Aldrich SML0184 Ginsenoside Rg3 ≥98% (HPLC) 14197-60-5 25mg $531 2024-03-01 Buy
Product number Packaging Price Buy
SML0184 5mg $128 Buy
64139 10mg $396 Buy
15332 5mg $32 Buy
15332 10mg $57 Buy
SML0184 25mg $531 Buy

Ginsenoside Rg3 Chemical Properties,Uses,Production

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg3 induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Uses

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Uses

Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).

Definition

ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.

Biochem/physiol Actions

Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.

Ginsenoside Rg3 Preparation Products And Raw materials

Raw materials

Preparation Products

Ginsenoside Rg3 Suppliers

Global( 282)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3772 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29881 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 sales@dolonchem.com CHINA 2972 58
NanJing Spring & Autumn Biological Engineering CO., LTD. 		+8613815430202 sale02@cqherb.com CHINA 376 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shanghai Standard Technology Co., Ltd. 		18502101150 ft-sales@nature-standard.com CHINA 1923 58
Supplier Advantage
Chengdu Biopurify Phytochemicals Ltd.
58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
NanJing Spring & Autumn Biological Engineering CO., LTD. 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Standard Technology Co., Ltd. 		58

Related articles

View Lastest Price from Ginsenoside Rg3 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ginsenoside Rg3 pictures 2024-04-12 Ginsenoside Rg3
14197-60-5
 US $0.00 / kg 1kg 98% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Ginsenoside Rg3 pictures 2023-02-24 Ginsenoside Rg3
14197-60-5
 US $0.00 / mg 5mg ≥96%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5 pictures 2022-02-14 Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5
14197-60-5
 US $365.00 / g 10mg 15% 50% 98% 100.00kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
  • Ginsenoside Rg3 pictures
  • Ginsenoside Rg3
    14197-60-5
  • US $0.00 / kg
  • 98%
  • Shaanxi Haibo Biotechnology Co., Ltd
  • Ginsenoside Rg3 pictures
  • Ginsenoside Rg3
    14197-60-5
  • US $0.00 / mg
  • ≥96%(HPLC)
  • Shanghai Standard Technology Co., Ltd.

14197-60-5(Ginsenoside Rg3)Related Search:

ginsenoside Rh(4) GINSENOSIDE RB2 Ginsenoside Rc Ginsenoside Rb1 Ginseng extract
GinsenosideRo Ginsenoside Rg2 PANAX NOTOGINSENOSIDES Ginsenoside Re Ginsenoside Rh2
Escin Ginsenoside Rg1 GINSENOSIDE RE TRIBULOSIDE Ginsenoside Rd
Ginsenoside Rf Ginsenoside CK 20(R)-Ginsenoside Rg3

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beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc eta-d-glucopyranosyl- gensenoside RG3 (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside Rg3 GINSENOSIDE RG3 opyransoyl)oxy)- 20(s)-ginsenoside-rg3 (20S)-PROPANAXADIOL Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D- glucopyranosyl-β-D-glucopyranosyl)oxy]- Ginsenoside 20(s)-Rg3 (20S)-3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]dammarane-24-ene-12β,20-diol 12β,20-Dihydroxy-5α-dammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside 20S-Ginseniside Rg3 Ginsenoside Rg3 (S-) (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside GINSENOSIDE RG3(S-FORM)(P) GINSENOSIDE Rg3(SH) Ginsenoside Rg3 ,98% Monomer Ginsenoside Rg3 (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL Ginsenoside Rg3, 98%, from Panax ginseng C. A. Mey. (11019-45-7) ginsenoside rg3 Ginsenoside Rg3, ≥98%(HPLC) 2-[[4,5-dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)-3-oxany CS-1328 Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5 Ginsenoside Rg3 (S-Form) β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl- (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Ginsenosides rg3(s) Ginsenoside S type Rg3 Ginsenoside Rg3(S-Form)(AS) 14197-60-5 C42H72O11 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Ginsenoside series Saponins The group of Ginsenosides