DIETHYLPHOSPHONOACETIC ACID
- CAS No.
- 3095-95-2
- Chemical Name:
- DIETHYLPHOSPHONOACETIC ACID
- Synonyms
- 2-(diethoxyphosphoryl)acetic acid;NSC 272281;Diethyl sulfonic acid;Venadaparib Impurity 39;acetyl diethyl phosphate;Diethylphosphoacetic acid;(diethoxyphosphoryl)acetate;DIETHYLPHOSPHONOACETIC ACID;2-diethoxyphosphorylacetate;DIETHYLPHOSPHONOETHANOIC ACID
- CBNumber:
- CB9724914
- Molecular Formula:
- C6H13O5P
- Molecular Weight:
- 196.14
- MDL Number:
- MFCD00192032
- MOL File:
- 3095-95-2.mol
- MSDS File:
- SDS
Boiling point | 150 °C/0.05 mmHg (lit.) |
---|---|
Density | 1.220 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | Viscous Liquid |
pka | 3.48±0.10(Predicted) |
color | Clear colorless to yellow |
Specific Gravity | 1.220 |
InChI | InChI=1S/C6H13O5P/c1-3-10-12(9,11-4-2)5-6(7)8/h3-5H2,1-2H3,(H,7,8) |
InChIKey | DVQMPWOLBFKUMM-UHFFFAOYSA-N |
SMILES | C(O)(=O)CP(OCC)(OCC)=O |
FDA UNII | 6L31G8862Z |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 37/39-26 |
WGK Germany | 3 |
HS Code | 29319090 |
DIETHYLPHOSPHONOACETIC ACID price More Price(35)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 268127 | Diethylphosphonoacetic acid 95% | 3095-95-2 | 5ml | $18.76 | 2024-03-01 | Buy |
Sigma-Aldrich | 268127 | Diethylphosphonoacetic acid 95% | 3095-95-2 | 25ml | $143 | 2024-03-01 | Buy |
TRC | D444745 | Diethylphosphonoacetic acid | 3095-95-2 | 25g | $140 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | ING0004122 | DIETHYLPHOSPHONOACETIC ACID 95.00% | 3095-95-2 | 5ML | $775.24 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | ING0004122 | DIETHYLPHOSPHONOACETIC ACID 95.00% | 3095-95-2 | 25ML | $1112.15 | 2021-12-16 | Buy |
DIETHYLPHOSPHONOACETIC ACID Chemical Properties,Uses,Production
Description
Diethylphosphonoacetic Acid (DPA) is a Horner-Wadsworth-Emmons (HWE) reagent. The mixed anhydride of trifluoroacetic acid—diethylphosphonoacetic acid Treat a 21-hydroxy-20-keto steroid leads directly to cardenolides by an intramolecular Horner-Emmons reaction. It could also used as a dummy template to prepare a molecularly imprinted polymer for use as an artificial receptor for organophosphorus pesticides (OPPs)[1-3].
Chemical Properties
clear colorless to yellow viscous liquid
Uses
Acts as a nucleophile for nucleophilic addition reactions for synthesis of allene epoxides
Reactant for:
- Stereoselectivity studies of the Staudinger reaction
- Enantioselective formation of diols via epoxidation and hydration reactions
- Horner-Wadsworth-Emmons reactions
- Remote chelation controlled Ireland-Claisen rearrangement
- Ugi-Dieckmann reactions for synthesis of tetramic acid derivatives
Uses
Diethylphosphonoacetic Acid is a reagent that is used for enantioselective preparation of α-phosphoryl-α,β-unsatd.-δ-aryl-δ-lactones from nonracemic β-hydroxyaldehydes and their conversion to α-methylene-δ-aryl-δ-lactones.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 4534, 1980 DOI: 10.1021/ja00533a047
References
[1] S. Donovan, J. Mcmurry, M. Avery. “Synthesis of digitoxigenin by remote functionalization.” Tetrahedron Letters 20 1 (1979): 3287–3290.
[2] A. M. Boldi, Hisham O. Eissa, Charles R. Johnson. “Solid-phase library synthesis of triazolopyridazines via [4+2] cycloadditions.” Tetrahedron Letters 40 1 (1999): 619–622.
[3] Lu Zhang. “Preparation and Characterization of Broad-Spectrum Artificial Antibody for OPPs Based on Dummy Template Imprinting Technique.” International Journal of Polymer Analysis and Characterization 117 1 (2014): 510–521.
DIETHYLPHOSPHONOACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Famo Biotech Co Ltd | +8618550473860 | mayan@famobiotech.com | China | 514 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3921 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5823 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
View Lastest Price from DIETHYLPHOSPHONOACETIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-19 | DIETHYLPHOSPHONOACETIC ACID
3095-95-2
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | ||
2024-08-11 | DIETHYLPHOSPHONOACETIC ACID
3095-95-2
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | ||
2024-05-09 | 2-(Diethoxyphosphinyl)acetic acid
3095-95-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
- DIETHYLPHOSPHONOACETIC ACID
3095-95-2
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
- DIETHYLPHOSPHONOACETIC ACID
3095-95-2
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
- 2-(Diethoxyphosphinyl)acetic acid
3095-95-2
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
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