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Chlortetracycline hydrochloride

CAS No.
64-72-2
Chemical Name:
Chlortetracycline hydrochloride
Synonyms
CHLORTETRACYCLINE HCL;CTC;AUREOMYCIN;CHLOROTETRACYCLINE HYDROCHLORIDE;CHLOROTETRACYCLINE HCL;AUREOMYCIN HYDROCHLORIDE;u-6780;nsc-13252;Auxeomycin;Isphamycin
CBNumber:
CB9737862
Molecular Formula:
C22H24Cl2N2O8
Molecular Weight:
515.34
MDL Number:
MFCD26142699
MOL File:
64-72-2.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Chlortetracycline hydrochloride Properties

Melting point 210-215 °C (dec.)(lit.)
alpha D23 -240°
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility 1 M NaOH: soluble50mg/mL
form Powder
color faint yellow to yellow
pka 3.3(at 25℃)
Water Solubility Soluble in water
Sensitive Light Sensitive
Merck 13,2211
BRN 3858364
CAS DataBase Reference 64-72-2(CAS DataBase Reference)
FDA UNII O1GX33ON8R
EPA Substance Registry System Chlortetracycline hydrochloride (64-72-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H315-H317-H319-H335-H361fd
Precautionary statements  P202-P261-P280-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  QI7800000
HazardClass  3
HS Code  29413020
Toxicity LD50 orally in rats: 10300 mg/kg (Goldenthal)

Chlortetracycline hydrochloride price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 26430 Chlortetracycline hydrochloride suitable for fluorescence, BioReagent, from 64-72-2 5g $70.5 2024-03-01 Buy
Sigma-Aldrich 46133 Chlortetracycline hydrochloride VETRANAL?, analytical standard 64-72-2 250mg $74.1 2024-03-01 Buy
Sigma-Aldrich 1129007 Chlortetracycline hydrochloride United States Pharmacopeia (USP) Reference Standard 64-72-2 200mg $447 2024-03-01 Buy
Alfa Aesar J60095 Chlortetracycline hydrochloride 64-72-2 25g $128 2024-03-01 Buy
Alfa Aesar J60095 Chlortetracycline hydrochloride 64-72-2 100g $378 2024-03-01 Buy
Product number Packaging Price Buy
26430 5g $70.5 Buy
46133 250mg $74.1 Buy
1129007 200mg $447 Buy
J60095 25g $128 Buy
J60095 100g $378 Buy

Chlortetracycline hydrochloride Chemical Properties,Uses,Production

Description

Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.

Chemical Properties

Yellow Solid

Uses

Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Uses

Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.

Uses

antibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis

Uses

An antimicrobial and antibacterial. This compound contains an undetermined amount of epi-chlortetracycline

brand name

Aureomycin (Lederle).

General Description

Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.

Purification Methods

Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]

Chlortetracycline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Chlortetracycline hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chlortetracycline hydrochloride pictures 2024-11-21 Chlortetracycline hydrochloride
64-72-2
US $0.00 / KG 1KG 99% 5tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Chlortetracycline hydrochloride pictures 2024-11-20 Chlortetracycline hydrochloride
64-72-2
US $0.00 / kg 25kg ≥97.0% 1tons Henan Suikang Pharmaceutical Co.,Ltd.
Chlortetracycline hydrochloride pictures 2024-11-19 Chlortetracycline hydrochloride
64-72-2
US $30.00 / mg 93.87% 10g TargetMol Chemicals Inc.
7-CHLORTETRACYCLINE MONOHYDROCHLORIDE 7-CHLOROTETRACYCLINE HCL 7-CHLOROTETRACYCLINE HYDROCHLORIDE 7-CHLOROTETRACYCLINE MONOHYDROCHLORIDE 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]- CHLOROTETRACYCLINE HYDROCHLORIDEVETRANAL , 250 MG CHLORTETRACYCLINE HYDROCHLORIDE FROM STR EPTOMYCES AUREOFACI Aureociclina, Isphamycin 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)- 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride 6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-ydro-monohydrochloride Aureociclina Aureocycline Auxeomycin chlortetracyclinehydrochloride’canbeusedassecondarystandard’ clorotetraciclinacloridrato Isphamycin nsc-13252 u-6780 CHLORTETRACYCLINE HYDROCHLORIDE AUREOMYCIN HCL AUREOMYCIN(TM) [4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride 2-NaphthacenecarboxaMide, 7-chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)- Chlorotetracy Chlorterracycline Hydrochloride Chlortetracycline hydrochloride Solution, 100ppm Chlortetracycline for system suitability Aureomycin/Chlortetracycline hcl 7-Chlorotetracycline hydrochloride CTC CHLORTETRACYCLINEHYDROCHLORIDE,CRYSTAL Auxeomycin hydrochloride. Chlortetracycline Hc1 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride 4-Chlorotetracycline hydrochloride Fermycin Soluble Biomycin hydrochloride CHLORTETRACYCLINE.HYDROCHLORIDERESEARCH GRADE Chlortetracycline hydrochloride, conforms to Eur. Ph. Chlortetracycline hydrochloride,7-Chlorotetracycline hydrochloride Chlortetracycline Hydrochloride (200 mg) Chlortetracycline Hydrochloride (200 mg)K0C1851008ug/mg(ai) (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-2-naphthacenecarboxaMide Hydrochloride AureoMycin Monohydrochloride Aureovit 12C80 Aurofac 100 ChlortetracycliniuM Chloride Chlortetracycline hydrochlorideCTC 7-Chlortetracycline hydrochloride, NSC 13252 Chlortetracycline hydrochloride, potency 900 ug/mg Chlortetracycline Hydrochloride Standard Chlortetracycline-d6 HCl Tetracycline Chloro HCl (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride Chlortetracycline hydrochloride USP/EP/BP ANALYSIS REPORT OF CTC FEED GRADE Chlortetracycline hydrochloride / Chlortetracycline hcl Chlortetracyclin hydrochloride