2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.

Chemische Eigenschaften

Yellow Solid

Verwenden

Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Allgemeine Beschreibung

Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.

läuterung methode

Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8812	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5893	58
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	294	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	852	58
Henan Suikang Pharmaceutical Co.,Ltd.	+86-18239973690 +86-18239973690	sales@suikangpharm.com	China	311	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58

64-72-2(2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-)Verwandte Suche:

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• 7-CHLORTETRACYCLINE MONOHYDROCHLORIDE
• 7-CHLOROTETRACYCLINE HCL
• 7-CHLOROTETRACYCLINE HYDROCHLORIDE
• 7-CHLOROTETRACYCLINE MONOHYDROCHLORIDE
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-
• CHLOROTETRACYCLINE HYDROCHLORIDEVETRANAL , 250 MG
• CHLORTETRACYCLINE HYDROCHLORIDE FROM STR EPTOMYCES AUREOFACI
• Aureociclina, Isphamycin
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride
• 6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-ydro-monohydrochloride
• Aureociclina
• Aureocycline
• Auxeomycin
• chlortetracyclinehydrochloride’canbeusedassecondarystandard’
• clorotetraciclinacloridrato
• Isphamycin
• nsc-13252
• u-6780
• CHLORTETRACYCLINE HYDROCHLORIDE
• AUREOMYCIN HCL
• AUREOMYCIN(TM)
• [4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
• 2-NaphthacenecarboxaMide, 7-chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
• Chlorotetracy
• Chlorterracycline Hydrochloride
• Chlortetracycline hydrochloride Solution, 100ppm
• Chlortetracycline for system suitability
• Aureomycin/Chlortetracycline hcl
• 7-Chlorotetracycline hydrochloride CTC
• CHLORTETRACYCLINEHYDROCHLORIDE,CRYSTAL
• Auxeomycin hydrochloride.
• Chlortetracycline Hc1
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride
• 4-Chlorotetracycline hydrochloride
• Fermycin Soluble
• Biomycin hydrochloride
• CHLORTETRACYCLINE.HYDROCHLORIDERESEARCH GRADE
• Chlortetracycline hydrochloride, conforms to Eur. Ph.
• Chlortetracycline hydrochloride,7-Chlorotetracycline hydrochloride
• Chlortetracycline Hydrochloride (200 mg)
• Chlortetracycline Hydrochloride (200 mg)K0C1851008ug/mg(ai)
• (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-2-naphthacenecarboxaMide Hydrochloride
• AureoMycin Monohydrochloride
• Aureovit 12C80
• Aurofac 100
• ChlortetracycliniuM Chloride
• Chlortetracycline hydrochlorideCTC
• 7-Chlortetracycline hydrochloride, NSC 13252
• Chlortetracycline hydrochloride, potency 900 ug/mg
• Chlortetracycline Hydrochloride Standard
• Chlortetracycline-d6 HCl
• Tetracycline Chloro HCl
• (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
• Chlortetracycline hydrochloride USP/EP/BP
• ANALYSIS REPORT OF CTC FEED GRADE
• Chlortetracycline hydrochloride / Chlortetracycline hcl
• Chlortetracyclin hydrochloride