BLEOMYCIN A5 HYDROCHLORIDE
- CAS No.
- 55658-47-4
- Chemical Name:
- BLEOMYCIN A5 HYDROCHLORIDE
- Synonyms
- BLEOCIN(TM);Bleomycin A5 HCl Salt;BLEOCIN(TM) ANTIBIOTIC;Bleomycin A5 Hydrochlorid;Bleomycin A5 Hydrochloride;Bleomycin A5 Hydrochloride Salt;BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP;BLEOCIN(TM), STREPTOMYCES VERTICILLUS;BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%;N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
- CBNumber:
- CB9762129
- Molecular Formula:
- C57H90ClN19O21S2
- Molecular Weight:
- 1477.03
- MDL Number:
- MFCD01740724
- MOL File:
- 55658-47-4.mol
| Melting point | >185°C (dec.) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| Stability | Hygroscopic |
| FDA UNII | T2UC5J38DD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H317-H319-H334-H335-H361d |
| Precautionary statements | P280-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338-P308+P313 |
BLEOMYCIN A5 HYDROCHLORIDE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19692 | Bleomycin A5 (hydrochloride) ≥85% | 55658-47-4 | 1mg | $25 | 2021-12-16 | Buy |
| Cayman Chemical | 19692 | Bleomycin A5 (hydrochloride) ≥85% | 55658-47-4 | 5mg | $113 | 2021-12-16 | Buy |
| Cayman Chemical | 19692 | Bleomycin A5 (hydrochloride) ≥85% | 55658-47-4 | 10mg | $200 | 2021-12-16 | Buy |
| Cayman Chemical | 19692 | Bleomycin A5 (hydrochloride) ≥85% | 55658-47-4 | 25mg | $438 | 2021-12-16 | Buy |
| Usbiological | 257225 | Bleomycin A5 hydrochloride | 55658-47-4 | 10mg | $406 | 2021-12-16 | Buy |
BLEOMYCIN A5 HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.
Biological Activity
bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.
in vitro
the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].
in vivo
in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].
References
[1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
[2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
[3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.
BLEOMYCIN A5 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2993 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
View Lastest Price from BLEOMYCIN A5 HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP
55658-47-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-03 | BleoMycin A5 Hydrochloride
55658-47-4
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-24 | BLEOMYCIN A5 HYDROCHLORIDE
55658-47-4
|
US $1.00 / g | 1g | 98%min | G/KG/T | Career Henan Chemical Co |
-
- BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP
55658-47-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- BleoMycin A5 Hydrochloride
55658-47-4
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- BLEOMYCIN A5 HYDROCHLORIDE
55658-47-4
- US $1.00 / g
- 98%min
- Career Henan Chemical Co
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