alpha-Amyrin
- CAS No.
- 638-95-9
- Chemical Name:
- alpha-Amyrin
- Synonyms
- A-AMYRIN;α-Amyrin;e-Amyrin;VIMINALOL;α-Amyrine;AMYRIN, A-;alfa-Amyrin;α-Amyrin-RM;ALPHA-AMYRIN;DELTA-AMYRIN
- CBNumber:
- CB9767508
- Molecular Formula:
- C30H50O
- Molecular Weight:
- 426.73
- MDL Number:
- MFCD00016754
- MOL File:
- 638-95-9.mol
- MSDS File:
- SDS
| Melting point | 178-183°C |
|---|---|
| alpha | D17 +91.6° (c = 1.3 in benzene) |
| Boiling point | bp0.7 243° |
| Density | 0.9600 (rough estimate) |
| refractive index | 1.4910 (estimate) |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 15.18±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| optical activity | +93.3 (c 5.55, C6H6) |
| BRN | 1916550 |
| LogP | 10.636 (est) |
| CAS DataBase Reference | 638-95-9(CAS DataBase Reference) |
| FDA UNII | 30ZAG40J8N |
| NIST Chemistry Reference | «ALPHA»-amyrin(638-95-9) |
| EPA Substance Registry System | Urs-12-en-3-ol, (3.beta.)- (638-95-9) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xi |
| WGK Germany | 3 |
alpha-Amyrin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 53017 | α-Amyrin analyticalstandard | 638-95-9 | 10mg | $322 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80705 | α-Amyrin phyproof? Reference Substance | 638-95-9 | 10MG | $410 | 2023-06-20 | Buy |
| TRC | A636915 | α-Amyrin | 638-95-9 | 10mg | $865 | 2021-12-16 | Buy |
| TRC | A636915 | α-Amyrin | 638-95-9 | 25mg | $1960 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0007063 | ALPHA-AMYRIN 95.00% | 638-95-9 | 10MG | $970.43 | 2021-12-16 | Buy |
alpha-Amyrin Chemical Properties,Uses,Production
Uses
a-Amyrin is a natural chemical compound of the triterpene class. It is a pentacyclic triterpenol widely distributed in nature and has been isolated from a variety of plant sources such as epicuticular wax.
Definition
ChEBI: A pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group.
Biological Activity
Triterpene th at has broad-spectrum analgesic properties for which the underlying mechanism is poorly understood but which may involve the inhibition of protein kinase A (PKA).
in vivo
α-Amyrin (50, 100, 200 mg/kg orally, once daily for 42 days) can reduce the survival rate of rats with metabolic syndrome induced by high fructose diet[2].
α-Amyrin (2 or 4 mg/kg, orally) improves cognitive dysfunction caused by low cholinergic neurotransmission in mice by activating ERK and GSK-3β signaling pathways[3].
| Animal Model: | High-fructose diet (HFD)-induced metabolic syndrome in rats[2] |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | p.o. |
| Result: | Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides. Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD. |
| Animal Model: | Scopolamine-Induced Memory Impairment Mice[3] |
| Dosage: | 2 or 4 mg/kg |
| Administration: | p.o. |
| Result: | Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β). |
Purification Methods
Purify it by acetylation to the acetate followed by hydrolysis and recrystallisation from aqueous MeOH or from EtOH. The acetate when crystallised from pet ether, n-heptane or CHC
alpha-Amyrin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 973 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 |
