Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-

Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl- structure

CAS No.: 396721-89-4

Chemical Name:: Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-

Synonyms: KL101;Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-

CBNumber:: CB98082157

Molecular Formula:: C22H23N3OS

Molecular Weight:: 377.5

MDL Number:

MOL File:: 396721-89-4.mol

Last updated:2023-04-23 13:52:06

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Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl- Properties

storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml)
form	solid
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl- Chemical Properties,Uses,Production

Description

KL101 (396721-89-4) is an isoform-selective stabilizer of the circadian clock protein CRY1.? It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. KL101 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics.

References

References/Citations:

Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, N-[2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl- KL101 396721-89-4