2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
![2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Structure](CAS/GIF/70006-24-5.gif)
- CAS No.
- 70006-24-5
- Chemical Name:
- 2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
- Synonyms
- ABT 724;ABT-724, 10 mM in DMSO;ABT 724 TRIHYDROCHLORIDE;2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole;1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-;2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole;2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE;ABT 724,Inhibitor,Dopamine Receptor,penile,erection,D4-receptor,Dopamine,ABT-724,inhibit,ABT724,potentiation,side-effect
- CBNumber:
- CB9850686
- Molecular Formula:
- C17H19N5
- Molecular Weight:
- 293.37
- MDL Number:
- MFCD05262347
- MOL File:
- 70006-24-5.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,2-8°C |
|---|---|
| form | solid |
| color | White |
| FDA UNII | 4WV2575JWT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P362+P364 |
| HS Code | 2933599590 |
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2214 | ABT-724 trihydrochloride ≥99%(HPLC) | 70006-24-5 | 10 | $144 | 2021-12-16 | Buy |
| Tocris | 2214 | ABT-724 trihydrochloride ≥99%(HPLC) | 70006-24-5 | 50 | $603 | 2021-12-16 | Buy |
| TRC | A112605 | ABT724 | 70006-24-5 | 50mg | $100 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000085 | ABT-724 95.00% | 70006-24-5 | 10MG | $697.34 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000085 | ABT-724 95.00% | 70006-24-5 | 50MG | $1170.31 | 2021-12-16 | Buy |
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
ABT 724 trihydrochloride is a potent dopamine D4 receptor agonist. ABT 724 is used in pharmacology systems for treating ocular disorders.
Definition
ChEBI: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole is a member of pyridines and a member of piperazines.
Biological Activity
Potent dopamine D 4 receptor partial agonist (EC 50 = 12.4 nM; 61% efficacy vs. dopamine). Has no agonist activity at D 2 receptors (EC 50 > 10 μ M). Selective in rats in vivo : produces penile erection following i.c.v. administration; increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. Displays minimal side effects.
in vivo
ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1].
| Animal Model: | Male adult Wistar rats (~300 g)[1] |
| Dosage: | 8.8 μg/kg |
| Administration: | Subcutaneous injection; daily; for 5 days |
| Result: | Dose-dependently facilitated penile erection. |
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
