YTX-465
- CAS No.
- 2225824-53-1
- Chemical Name:
- YTX-465
- Synonyms
- YTX-465;YTX-465Chemical Structure;Benzamide, N-[2-[4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-2-oxoethyl]-;YTX-465,α-synuclein,YTX465,fatty desaturation,Stearoyl-CoA Desaturase (SCD),Inhibitor,YTX 465,Parkinson’s disease,inhibit,synucleinopathies
- CBNumber:
- CB99636780
- Molecular Formula:
- C25H26N6O3
- Molecular Weight:
- 458.51
- MDL Number:
- MOL File:
- 2225824-53-1.mol
YTX-465 Chemical Properties,Uses,Production
Biological Activity
YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson's disease and other synucleinopathies[1]. YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue[1].YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast[1].YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop[1].YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM[1].YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast[1].
References
[1]. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.
YTX-465 Preparation Products And Raw materials
Raw materials
Preparation Products
YTX-465 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| Guangzhou Ruitai Chemical Co., Ltd. | 18344585702 | 550795326@qq.com | China | 83 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8018 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9863 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9242 | 58 |
| Fujian boshi pharmaceutical technology co. LTD | 18120708884 | 393612455@qq.com | China | 255 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |