ChemicalBook >> CAS DataBase List >>Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)-
Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)-
- CAS No.
- 2170140-50-6
- Chemical Name:
- Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)-
- Synonyms
- (R)-GSK-3685032;Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)-
- CBNumber:
- CB99940344
- Molecular Formula:
- C22H24N6OS
- Molecular Weight:
- 420.54
- MDL Number:
- MOL File:
- 2170140-50-6.mol
Last updated:2024-07-02 08:55:42
Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Properties
Boiling point | 669.4±55.0 °C(Predicted) |
---|---|
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | 4°C, away from moisture and light |
solubility | DMSO : 60 mg/mL (142.68 mM; Need ultrasonic) |
form | Solid |
pka | 14.65±0.50(Predicted) |
color | White to off-white |
Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Chemical Properties,Uses,Production
Biological Activity
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].
References
[1]. Adams, Nicholas David, et al. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727A1. [2]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017.
Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Suppliers
Global( 5)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 403 | 58 |
Wuhan WinYuanBei Trading Company | 86-13349903920; 13349903920 | 869523959@qq.com | China | 9656 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)-
(R)-GSK-3685032
2170140-50-6