5-Bromo-thiophene-2-carboxylic acid methyl ester

5-Bromo-thiophene-2-carboxylic acid methyl ester Structure
CAS No.
62224-19-5
Chemical Name:
5-Bromo-thiophene-2-carboxylic acid methyl ester
Synonyms
5-broMo-;Methyl 2-broMothiophene-5...;2-Bromo-5-(methoxycarbonyl)thiophene;Methyl 2-broMothiophene-5-carboxylate;Methyl 5-bromo-2-thiophenecarboxylate;methyl 5-bromothiophene-2-carboxylate;5-bromo-2-thiophenecarboxylic acid methyl ester;5-Bromo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-bromo-, methyl ester
CBNumber:
CB01113336
Molecular Formula:
C6H5BrO2S
Molecular Weight:
221.07
MOL File:
62224-19-5.mol
Modify Date:
2023/1/11 10:46:38

5-Bromo-thiophene-2-carboxylic acid methyl ester Properties

Melting point 87-88℃
Boiling point 251.9±20.0 °C(Predicted)
Density 1.662±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P271-P260-P280
HS Code  2932990090

5-Bromo-thiophene-2-carboxylic acid methyl ester Chemical Properties,Uses,Production

Uses

Methyl 5-Bromo-2-thiophenecarboxylate is used as a reagent in the synthesis of trisubstituted isoxazole derivatives which are novel nonsteroidal antagonists of Farnesoid X Receptor (FXR). FXR plays an important role in regulation of cholesterol, lipid and glucose metabolism.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 1109, 1992 DOI: 10.1021/jm00084a016

5-Bromo-thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-thiophene-2-carboxylic acid methyl ester Spectrum

5-Bromo-thiophene-2-carboxylic acid methyl ester Methyl 5-bromo-2-thiophenecarboxylate 5-broMo- Methyl 2-broMothiophene-5... Methyl 2-broMothiophene-5-carboxylate 2-Thiophenecarboxylic acid, 5-bromo-, methyl ester methyl 5-bromothiophene-2-carboxylate 5-bromo-2-thiophenecarboxylic acid methyl ester 2-Bromo-5-(methoxycarbonyl)thiophene 62224-19-5 API intermediates