Pyronaridine
- CAS No.
- 74847-35-1
- Chemical Name:
- Pyronaridine
- Synonyms
- Pyronaridine;Malaridine phosphate;4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-...;4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol;4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol;4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol;Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-;4-[(7-CHLORO-2-METHOXY-1,5-DIHYDROBENZO[B][1,5]NAPHTHYRIDIN-10-YL)IMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)CYCLOHEXA-2,5-DIEN-1-ONE
- CBNumber:
- CB01179619
- Molecular Formula:
- C29H32ClN5O2
- Molecular Weight:
- 518.05
- MOL File:
- 74847-35-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/7 12:04:01
| Boiling point | 621.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.356±0.06 g/cm3 (20℃ 760 Torr) |
| refractive index | 1.5650 (estimate) |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Solid |
| pka | 8.20±0.50(Predicted) |
| color | Light Yellow to Orange |
| Stability | Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 74847-35-1 |
Pyronaridine Chemical Properties,Uses,Production
Chemical Properties
solid
Antimicrobial activity
Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.
Acquired resistance
Decreasing in-vitro sensitivity has been observed in China.
Pharmaceutical Applications
An aza-aminoacridine formulated for oral use. A Mannichbase derivative of mepacrine.
Pharmacokinetics
Peak plasma concentrations are reached after 3–14 h depending upon the formulation; there is also considerable interindividual variation. Elimination half-lives of 63–190 h have been reported, again dependent upon the formulation.
Clinical Use
Treatment of uncomplicated P. falciparum and P. vivax malaria
A fixed-dose combination with artesunate (Pyramax) is being
developed for uncomplicated P. falciparum and P. vivax malaria.
Side effects
It is well tolerated and no outstanding toxic effects have been reported.
Pyronaridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| airuikechemical co., ltd. | +undefined86-15315557071 | China | 983 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21663 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9261 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |