3-AP
- CAS No.
- 143621-35-6
- Chemical Name:
- 3-AP
- Synonyms
- 3-AP;Pan811;3-Apct;Pan-811;Pan 811;C078157;OCX 191;CS-2006;Triapine;OCX 0191
- CBNumber:
- CB01314063
- Molecular Formula:
- C7H9N5S
- Molecular Weight:
- 195.24
- MOL File:
- 143621-35-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 15:50:00
| Melting point | 234 °C |
|---|---|
| Boiling point | 436.0±55.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10Meq/mL, clear |
| pka | 10.93±0.70(Predicted) |
| form | powder |
| color | white to light brown |
| CAS DataBase Reference | 143621-35-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.39.6190 | |||||||||
| Toxicity | LDLo ivn-rat: 20 mg/kg IJTOFN 19,85,2000 | |||||||||
| NFPA 704 |
|
3-AP price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0568 | 3-AP ≥98% (HPLC) | 143621-35-6 | 5MG | ₹9277.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0568 | 3-AP ≥98% (HPLC) | 143621-35-6 | 25MG | ₹37530.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A3132 | 2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide | 143621-35-6 | 25MG | ₹9800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3132 | 2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide | 143621-35-6 | 100MG | ₹28300 | 2022-05-26 | Buy |
3-AP Chemical Properties,Uses,Production
Uses
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.[Cayman Chemical]
Hazard
A poison.
Safety Profile
A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx, and SOx,.
3-AP Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26165 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |