CAPSAZEPINE
- CAS No.
- 138977-28-3
- Chemical Name:
- CAPSAZEPINE
- Synonyms
- Capsazepin;CAPSAZEPINE;capasazepine;Capsazepine,98%;Capsazepine, 10 mM in DMSO;Capsazepine, TRPV1 antagonist;CAPSAZEPINE SYNTHETIC ANALOG OF C;8-dihydroxy-2H-2-benzazepine-2-carbothioamide;7;8-DIHYDROXY-2H-2-BENZAZEPINE-2-CARBOTHIOAMIDE;N-(4-Chlorophenethyl)-7,8-dihydroxy-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide
- CBNumber:
- CB0144302
- Molecular Formula:
- C19H21ClN2O2S
- Molecular Weight:
- 376.9
- MOL File:
- 138977-28-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 155-157°C |
|---|---|
| Boiling point | 581.1±60.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble |
| form | solid |
| pka | 9.73±0.20(Predicted) |
| color | off-white |
| InChIKey | DRCMAZOSEIMCHM-UHFFFAOYSA-N |
| CAS DataBase Reference | 138977-28-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Hazard statements | H402 |
|---|---|
| Precautionary statements | P273-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
CAPSAZEPINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C191 | Capsazepine ≥98% (HPLC), solid | 138977-28-3 | 5MG | ₹18402.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C191 | Capsazepine ≥98% (HPLC), solid | 138977-28-3 | 25MG | ₹72646.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 211280 | Capsazepine - CAS 138977-28-3 - Calbiochem A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 μM) blocks capsaicin (60 nM) stimulated firing of C-fibers. | 138977-28-3 | 10MG | ₹41350 | 2022-06-14 | Buy |
CAPSAZEPINE Chemical Properties,Uses,Production
Description
Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain. Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-
Chemical Properties
Light Yellow Solid
Uses
Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.
Definition
ChEBI: A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of caps icin, it was the first reported capsaicin receptor antagonist.
Hazard
A poison.
Biological Activity
Selective vanilloid receptor antagonist (K i = 3.2 μ M). Inhibits carrageenan inflammation-induced hyperalgesic responses in the rat. Also activates amiloride-sensitive epithelial Na + channel ENaC δ . Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
CAPSAZEPINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 12185 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32202 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | China | 52849 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49734 | 58 | Inquiry |
| TargetMol Chemicals Inc. | United States | 38636 | 58 | Inquiry |