TIN PROTOPORPHYRIN IX DICHLORIDE
- CAS No.
- 14325-05-4
- Chemical Name:
- TIN PROTOPORPHYRIN IX DICHLORIDE
- Synonyms
- SnPPIX;Nsc267099;TINPROTOPORPHYRIN;Tin protoporphyrin I;tin protoporphyrin IX;TIN PROTOPORPHYRIN IX DICHLORIDE;Tin Protoporphyrin IX (chloride);Tinprotoporphyrin IX,Tin protoporphyrin IX;Tin Protoporphyrin IX dichloride (NSC 267099;Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid]
- CBNumber:
- CB0148951
- Molecular Formula:
- C34H36Cl2N4O4Sn
- Molecular Weight:
- 754.29
- MOL File:
- 14325-05-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
TIN PROTOPORPHYRIN IX DICHLORIDE Chemical Properties,Uses,Production
Uses
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical]
TIN PROTOPORPHYRIN IX DICHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40067 | 58 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9806 | 58 | Inquiry |