3-(4-Pyridyl)indole
- CAS No.
- 7272-84-6
- Chemical Name:
- 3-(4-Pyridyl)indole
- Synonyms
- 3-(4-Pyridyl);3-(4-Pyridinyl)-;ROCK Inhibitor III;3-(4-Pyridyl)indole;Rho Kinase Inhibitor III;3-(4-Pyridinyl)-1H-indole;1H-Indole, 3-(4-pyridinyl)-;Rho Kinase Inhibitor III, Rockout;RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT;Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
- CBNumber:
- CB01564970
- Molecular Formula:
- C13H10N2
- Molecular Weight:
- 194.23
- MOL File:
- 7272-84-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:09
| storage temp. | +2C to +8C |
|---|---|
| solubility | DMSO, Methanol |
| form | Yellow solid |
| color | Yellow |
| Stability | Light Sensitive |
| CAS DataBase Reference | 7272-84-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501 | |||||||||
| NFPA 704 |
|
3-(4-Pyridyl)indole price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 555553 | Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem The Rho Kinase Inhibitor III, Rockout, also referenced under CAS 7272-84-6, controls the biological activity of Rho Kinase. This small molecule/inhibi | 7272-84-6 | 10MG | ₹13100 | 2022-06-14 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| 555553 | 10MG | ₹13100 | Buy |
3-(4-Pyridyl)indole Chemical Properties,Uses,Production
Description
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.
Chemical Properties
Yellow Solid
Uses
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]
General Description
A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 μM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 μM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 μM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 μM.
3-(4-Pyridyl)indole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9268 | 58 | Inquiry |
| ApexBio Technology | + 1-832-696-8203 | United States | 6254 | 58 | Inquiry |
| Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
| Shanghai Yuqi Biological Technology Co., Ltd. | 18930788570 | CHINA | 6087 | 58 | Inquiry |
| Boao Pike | 010-57798038 15652371397 | CHINA | 6629 | 58 | Inquiry |
| Beijing Huaxia Ocean Technology Co., Ltd. | 010-62898668 15311620006 | CHINA | 6122 | 58 | Inquiry |
| Shenzhen Xinbosheng Biological Technology Co., Ltd. | 0755-26755892 | CHINA | 6164 | 58 | Inquiry |