MYRIOCIN
- CAS No.
- 35891-70-4
- Chemical Name:
- MYRIOCIN
- Synonyms
- ISP-1;ISP-I;C001996;MYRIOCIN;6e))-4s*;NSC 177379;THERMOZYMOCIDIN;Spi-1 inhibitor;Myriocin (ISP-1);Isp-1 suppressant
- CBNumber:
- CB0207522
- Molecular Formula:
- C21H39NO6
- Molecular Weight:
- 401.54
- MOL File:
- 35891-70-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:06
| Melting point | 170-172℃ |
|---|---|
| Boiling point | 636.7±55.0 °C(Predicted) |
| Density | 1.123±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: 2 mg/mL |
| form | powder |
| pka | 1.79±0.50(Predicted) |
| color | off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| InChIKey | ZZIKIHCNFWXKDY-XFXZXTDPSA-N |
| CAS DataBase Reference | 35891-70-4 |
MYRIOCIN price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M1177 | Myriocin from Mycelia sterilia ≥98% (HPLC), powder | 35891-70-4 | 5MG | ₹7934.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M1177 | Myriocin from Mycelia sterilia ≥98% (HPLC), powder | 35891-70-4 | 25MG | ₹31197.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 476300 | Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem A potent immunosuppressant. | 35891-70-4 | 5MG | ₹14100 | 2022-06-14 | Buy |
MYRIOCIN Chemical Properties,Uses,Production
Description
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10-
Chemical Properties
White powder
Uses
Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin i s a useful biochemical research tool for depleting cells of sphingolipids.
Definition
ChEBI: An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
General Description
A potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
MYRIOCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | China | 25014 | 65 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
| Hubei Nordina Biotechnology Co., Ltd. | 18162687220 18162687220 | China | 2999 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
35891-70-4(MYRIOCIN)Related Search:
1of4
chevron_right