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3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Structure
CAS No.
202821-81-6
Chemical Name:
3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE
Synonyms
BMS-A;BMS 191011;-1,3,4-oxadiazol-2(3H);-5-(4-(trifluoromethyl);-5-(4-(trifluoromethyl);BMS-191011 >=98% (HPLC);3-(5-Chloro-2-hydroxybenzyl);3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoroMethyl)phenyl)-1,3,4;3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one;3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE
CBNumber:
CB02450344
Molecular Formula:
C16H10ClF3N2O3
Molecular Weight:
370.71
MOL File:
202821-81-6.mol
Modify Date:
2023/9/4 16:42:00
Request For Quotation

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Properties

Boiling point 444.0±55.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility DMSO: soluble20mg/mL, clear (warmed)
pka 9.27±0.43(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
NFPA 704
0
2 0

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0866 BMS-191011 ≥98% (HPLC) 202821-81-6 5MG ₹11506.98 2022-06-14 Buy
Sigma-Aldrich(India) SML0866 BMS-191011 ≥98% (HPLC) 202821-81-6 25MG ₹46374.3 2022-06-14 Buy
Product number Packaging Price Buy
SML0866 5MG ₹11506.98 Buy
SML0866 25MG ₹46374.3 Buy

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Chemical Properties,Uses,Production

Description

BMS 191011 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human KCa1.1 channels when used at a concentration of 1 μM. In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the KCa1.1 channel blocker iberiotoxin .

Biological Activity

Potent Maxi-K channel opener (large-conductance Ca 2+ -activated potassium channel, K Ca 1.1, BK Ca ). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Suppliers

Global( 81)Suppliers
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ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
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Aromsyn Co., Ltd. +86-0571-85585865 +8613336024896 China 19185 58 Inquiry
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Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
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Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
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Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
RR Scientific LLC 58
Aromsyn Co., Ltd. 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Amadis Chemical Company Limited 58

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Spectrum

3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE(202821-81-6)1HNMR

202821-81-6(3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE)Related Search:

Z-NHNH2 HCL 3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE
3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE BMS 191011 3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one 3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoroMethyl)phenyl)-1,3,4 -5-(4-(trifluoromethyl) -1,3,4-oxadiazol-2(3H) BMS-191011 >=98% (HPLC) 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]- BMS-A -5-(4-(trifluoromethyl) 3-(5-Chloro-2-hydroxybenzyl) Potassium Channel,rodent models of stroke,Panc-1,neuroprotective activity,inhibit,IGR39,BMS-191011,Inhibitor,BMS 191011,KcsA,BMS191011 202821-81-6 C16H10ClF3N2O3 C16H10ClF3N3O3