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3-O-Decladinosyl-6-O-Methylerythronolide A

3-O-Decladinosyl-6-O-Methylerythronolide A Structure
CAS No.
118058-74-5
Chemical Name:
3-O-Decladinosyl-6-O-Methylerythronolide A
Synonyms
DesclarithoMycin;3-hydroxyclarithromycin;Clarithromycin Impurity I;Clarithromycin EP Impurity I;De(cladinosyl) ClarithroMycin;Des(cladinosyl) Clarithromycin;Clarithromycin related compound I;(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R);5-O-DesosaMinyl-6-O-Methylerythronolide A;3-O-Decladinosyl-6-O-methylerythromycin A
CBNumber:
CB02620909
Molecular Formula:
C30H55NO10
Molecular Weight:
589.77
MOL File:
118058-74-5.mol
Modify Date:
2023/5/4 15:15:35

3-O-Decladinosyl-6-O-Methylerythronolide A Properties

Melting point 158-160 °C
Boiling point 708.6±60.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 13.10±0.70(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P

3-O-Decladinosyl-6-O-Methylerythronolide A Chemical Properties,Uses,Production

Uses

De(cladinosyl) Clarithromycin is an impurity of Clarithromycin (C559750). De(cladinosyl) Clarithromycin showed significantly potent antibacterial activity against community acquired respiratory pathogens.

3-O-Decladinosyl-6-O-Methylerythronolide A Preparation Products And Raw materials

Raw materials

Preparation Products

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3-O-De(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)-6-O-MethylerythroMycin 5-O-DesosaMinyl-6-O-Methylerythronolide A De(cladinosyl) ClarithroMycin DesclarithoMycin Des(cladinosyl) Clarithromycin (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecan Clarithromycin Impurity 9(Clarithromycin EP Impurity I) Clarithromycin EP Impurity I Clarithromycin Impurity I Clarithromycin related compound I 3-hydroxyclarithromycin Clarithromycin EP Impurity I/(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R) Erythromycin, 3-O-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)-6-O-methyl- Clarithromycin EP Impurity I (Des(cladinosyl) Clarithromycin/ 3-O-Decladinosyl-6-O-methylerythromycin A) 3-O-Decladinosyl-6-O-methylerythromycin A (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (Clarithromycin Impurity) Clarithromycin related compound I, EvoPure Decladinosyl Clarithromycin (25 mg) (3-O-De(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)-6-O-methylerythromycin 3-O-Decladinosyl-6-O-Methylerythronolide A (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradeca (2R,3S,4R,5R,7R,9R,10R,11S,12S,13R)-10-[(4-dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy]-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane 118058-74-5 C30H55NO10 Chiral Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Chiral Reagents Impurities Intermediates & Fine Chemicals Pharmaceuticals