TAK 599
- CAS No.
- 400827-46-5
- Chemical Name:
- TAK 599
- Synonyms
- TAK 599;PPI 0903;Ceftaroline fosaMil;C22H22N8O8PS4. C2H3O2;Ceftaroline Fosamil Acetate;TAK-599 (ceftaroline fosamil);Ceftaroline fosamil acetate salt;Ceftaroline Fosamil Acetate Impurity;TAK-599; CEFTAROLINE FOSAMIL;TAK599; TAK 599;PPI-0903;PPI0903;PPI 0903;N-phosphono,PPI 0903,inhibit,TAK599,MRSA,TAK 599,PPI-0903,T-91825,Bacterial,Inhibitor,Antibiotic,infection,Ceftaroline fosamil,prodrug
- CBNumber:
- CB02628440
- Molecular Formula:
- C24H25N8O10PS4
- Molecular Weight:
- 744.72
- MOL File:
- 400827-46-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:54:57
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334-H302 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P264-P270-P301+P312-P330-P501 |
TAK 599 Chemical Properties,Uses,Production
Description
Ceftaroline fosamil, also referred to as TAK-599, is a cephalosporin antibacterial agent that was approved in the United States in October 2010 for the IV treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Ceftaroline fosamil is the water-soluble, N-phosphono prodrug of ceftaroline (T-91825), a broad-spectrum, bactericidal agent with potent activity against methicillin-resistant Staphylococcus aureus (MRSA) strains, multidrug resistant S. pneumonia, and common gram-negative organisms. Ceftaroline binds to PBP2a as well as other PBPs with high affinity and, as a result, retains potent activity. Ceftaroline exhibits activity against most gram-positive pathogens, including β-lactam-susceptible and -resistant S. aureus, vancomycin-resistant S. aureus, and resistant and susceptible forms of S. pneumoniae but has weak activity against Enterococcus sp. The gram-negative antibacterial activity of ceftaroline is limited mainly to respiratory pathogens such as Moraxella catarrhalis and Haemophilus influenzae.
Definition
ChEBI: An acetate salt obtained by reaction of ceftaroline fosamil with one equivalent of acetic acid. A prodrug for ceftaroline, used for the treatment of adults with acute bacterial skin and skin structure infections.
TAK 599 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aavyan Labs | +91-9652399498 +91-9652399498 | Telangana, India | 60 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | China | 5990 | 58 | Inquiry |
| changzhou huayang technology co., ltd | +8615250961469 | China | 9827 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
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