PIPERAZINE DIHYDROCHLORIDE
- CAS No.
- 142-64-3
- Chemical Name:
- PIPERAZINE DIHYDROCHLORIDE
- Synonyms
- dowzenedhc;Piperazine 2HCl;dihydropipwormer;PIPERAZINE DI HCL;piperazinewormerpremix;Piperazine hydrate CRS;piperazinehydrochloride;Piperazinium Dichloride;PIPERAZINE DIHYDROCHLORIDE;Olaparib Impurity 10 DiHCl
- CBNumber:
- CB0264741
- Molecular Formula:
- C4H12Cl2N2
- Molecular Weight:
- 159.06
- MOL File:
- 142-64-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/29 18:52:01
| Melting point | 320°C(dec.)(lit.) |
|---|---|
| Boiling point | 262.01°C (rough estimate) |
| Density | 1.3011 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Water |
| form | White crystalline solid |
| color | White to Off-White |
| InChI | InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H |
| InChIKey | CVVIJWRCGSYCMB-UHFFFAOYSA-N |
| SMILES | C1NCCNC1.Cl.Cl |
| LogP | -1.171 (est) |
| CAS DataBase Reference | 142-64-3(CAS DataBase Reference) |
| EPA Substance Registry System | Piperazine dihydrochloride (142-64-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H334-H361fd-H412 | |||||||||
| Precautionary statements | P202-P261-P273-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 22-26-36/37 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 5 mg/m3 | |||||||||
| RTECS | TL4025000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 2933599550 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967. | |||||||||
| NFPA 704 |
|
PIPERAZINE DIHYDROCHLORIDE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | P2491 | Piperazine Dihydrochloride | 142-64-3 | 1G | ₹3500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2491 | Piperazine Dihydrochloride | 142-64-3 | 5G | ₹8900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0450 | Piperazine Dihydrochloride Monohydrate | 142-64-3 | 25G | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0450 | Piperazine Dihydrochloride Monohydrate | 142-64-3 | 500G | ₹10800 | 2022-05-26 | Buy |
PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.
General Description
White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).
Reactivity Profile
PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.
Potential Exposure
Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.
Carcinogenicity
Piperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.
Purification Methods
Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]
Incompatibilities
Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| SL Drugs & Pharmaceuticals | +91-4023840292 +91-4023840292 | Hyderabad, India | 12 | 58 | Inquiry |
| Lycos Chemtech | +91-9328485981 +91-9328485981 | Gujarat, India | 9 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Adani Pharmachem Pvt Ltd | +91-7573044087 +91-9974652373 | Gujarat, India | 27 | 58 | Inquiry |
| G Amphray Laboratories | +91-2222663150 +91-9820084212 | Maharashtra, India | 13 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| SL Drugs & Pharmaceuticals | 58 |
| Lycos Chemtech | 58 |
| JSK Chemicals | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Adani Pharmachem Pvt Ltd | 58 |
| G Amphray Laboratories | 58 |
| SynZeal Research Pvt Ltd | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Pharma Affiliates | 58 |
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