POLYOXIN D

POLYOXIN D Structure
CAS No.
22976-86-9
Chemical Name:
POLYOXIN D
Synonyms
polyoxinz;polyoxorim;POLYOXIN D;POLYOXIN D, STREPTOMYCES CACAOI VAR ASOENSIS;Polyoxin D,?Streptomyces cacaoi var. asoensis CURRENTLY UNAVAILABLE;2,3,4-tetrahydro-2,4-dioxo-d-allofuranuronosyl)-monocarbamate(ester);1-(5-(2-amino-2-deoxy-l-xylonamido)-5-deoxy-beta-5-pyrimidinecarboxylicaci;1-[5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-5-deoxy-β-D-allofuranulonosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyridinecarboxylic acid;1-[5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-5-deoxy-β-D-allofuranuronosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid;β-D-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy-
CBNumber:
CB0265177
Molecular Formula:
C17H23N5O14
Molecular Weight:
521.39
MOL File:
22976-86-9.mol
MSDS File:
SDS
Modify Date:
2022/12/21 16:56:50

POLYOXIN D Properties

Melting point 173-175 °C (decomp)
Density 1.864±0.06 g/cm3(Predicted)
pka 2.67±0.10(Predicted)

POLYOXIN D Chemical Properties,Uses,Production

Uses

Polyoxin D,?Streptomyces cacaoi var. asoensis is a specific inhibitor of fungal chitin synthetase.

Definition

ChEBI: A member of the class of polyoxins that is isolated from the soil organism Streptomyces cacaoi var. asoensis. Polyoxorim exhibits fungicidal properties and may be used on rice, industrial grounds, golf courses and parks.

Enzyme inhibitor

This pyrimidin nucleoside analogue and antifungal antibiotic (FWfree-acid = 521.39 g/mol; CAS 22976-86-9; 33401-46-6 for the zinc salt), produced by soil organisms Streptomyces cacaoi and S. piomogenus, inhibits chitin biosynthesis, Ki = 6 μM, thereby blocking septum formation. The zinc salt of polyyoxin is used to control Rice Sheath Blight, caused by the fungus Rhizoctonia solani, as well as the turfgrass disease Brown Patch, caused by other Rhizoctonia species. Polyoxin D also inhibits Neurospora crassa, but is nontoxic to land mammals, insects, or birds, when applied to plants as the wettable powder form known as Endorse?. Target(s): chitin synthase (1- 24); chitin synthase B; chitin synthase, canChs1A; WdChs4p, a chitin synthase 3 homologue.

POLYOXIN D Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,4-tetrahydro-2,4-dioxo-d-allofuranuronosyl)-monocarbamate(ester) polyoxinz polyoxorim 1-[5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-5-deoxy-β-D-allofuranulonosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyridinecarboxylic acid 1-[5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-5-deoxy-β-D-allofuranuronosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid POLYOXIN D POLYOXIN D, STREPTOMYCES CACAOI VAR ASOENSIS 1-(5-(2-amino-2-deoxy-l-xylonamido)-5-deoxy-beta-5-pyrimidinecarboxylicaci β-D-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy- Polyoxin D,?Streptomyces cacaoi var. asoensis CURRENTLY UNAVAILABLE 22976-86-9 C17H23N5O14